Cardiac Regeneration and Stem Cells

After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of c...

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Published inPhysiological reviews Vol. 95; no. 4; pp. 1189 - 1204
Main Authors Zhang, Yiqiang, Mignone, John, MacLellan, W. Robb
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.10.2015
Subjects
Animals
Cell Differentiation - physiology
Cellular biology
Heart
Heart - physiology
Heart Diseases - physiopathology
Humans
Maturation
Myocytes, Cardiac - physiology
Physiology
Regeneration - physiology
Reviews
Stem cells
Stem Cells - physiology
Tissue engineering
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Abstract After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of cardiac regeneration and led to a dramatic increase in our understanding of cardiac growth and repair, it has left much confusion in the field as to the prospects of regenerating the heart. Studies applying modern techniques of genetic lineage tracing and carbon-14 dating have begun to establish limits on the amount of endogenous regeneration after cardiac injury, but the underlying cellular mechanisms of this regeneration remained unclear. These same studies have also revealed an astonishing capacity for cardiac repair early in life that is largely lost with adult differentiation and maturation. Regardless, this renewed focus on cardiac regeneration as a therapeutic goal holds great promise as a novel strategy to address the leading cause of death in the developed world.
AbstractList After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of cardiac regeneration and led to a dramatic increase in our understanding of cardiac growth and repair, it has left much confusion in the field as to the prospects of regenerating the heart. Studies applying modern techniques of genetic lineage tracing and carbon-14 dating have begun to establish limits on the amount of endogenous regeneration after cardiac injury, but the underlying cellular mechanisms of this regeneration remained unclear. These same studies have also revealed an astonishing capacity for cardiac repair early in life that is largely lost with adult differentiation and maturation. Regardless, this renewed focus on cardiac regeneration as a therapeutic goal holds great promise as a novel strategy to address the leading cause of death in the developed world.
After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of cardiac regeneration and led to a dramatic increase in our understanding of cardiac growth and repair, it has left much confusion in the field as to the prospects of regenerating the heart. Studies applying modern techniques of genetic lineage tracing and carbon-14 dating have begun to establish limits on the amount of endogenous regeneration after cardiac injury, but the underlying cellular mechanisms of this regeneration remained unclear. These same studies have also revealed an astonishing capacity for cardiac repair early in life that is largely lost with adult differentiation and maturation. Regardless, this renewed focus on cardiac regeneration as a therapeutic goal holds great promise as a novel strategy to address the leading cause of death in the developed world.After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of cardiac regeneration and led to a dramatic increase in our understanding of cardiac growth and repair, it has left much confusion in the field as to the prospects of regenerating the heart. Studies applying modern techniques of genetic lineage tracing and carbon-14 dating have begun to establish limits on the amount of endogenous regeneration after cardiac injury, but the underlying cellular mechanisms of this regeneration remained unclear. These same studies have also revealed an astonishing capacity for cardiac repair early in life that is largely lost with adult differentiation and maturation. Regardless, this renewed focus on cardiac regeneration as a therapeutic goal holds great promise as a novel strategy to address the leading cause of death in the developed world.
Author Mignone, John
MacLellan, W. Robb
Zhang, Yiqiang
Author_xml – sequence: 1
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  surname: Zhang
  fullname: Zhang, Yiqiang
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– sequence: 2
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  surname: Mignone
  fullname: Mignone, John
  organization: Center for Cardiovascular Biology, Institute for Stem Cell Research and Division of Cardiology, Departments of Medicine and Pathology, University of Washington, Seattle, Washington
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  surname: MacLellan
  fullname: MacLellan, W. Robb
  organization: Center for Cardiovascular Biology, Institute for Stem Cell Research and Division of Cardiology, Departments of Medicine and Pathology, University of Washington, Seattle, Washington
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26269526$$D View this record in MEDLINE/PubMed
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Snippet After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be...
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StartPage 1189
SubjectTerms Animals
Cell Differentiation - physiology
Cellular biology
Heart
Heart - physiology
Heart Diseases - physiopathology
Humans
Maturation
Myocytes, Cardiac - physiology
Physiology
Regeneration - physiology
Reviews
Stem cells
Stem Cells - physiology
Tissue engineering
Title Cardiac Regeneration and Stem Cells
URI https://www.ncbi.nlm.nih.gov/pubmed/26269526
https://www.proquest.com/docview/1715979495
https://www.proquest.com/docview/1704348667
https://www.proquest.com/docview/1785229066
https://pubmed.ncbi.nlm.nih.gov/PMC4600953
Volume 95
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