Cardiac Regeneration and Stem Cells

• Published in: Physiological reviews Vol. 95; no. 4; pp. 1189 - 1204
• Main Authors: Zhang, Yiqiang, Mignone, John, MacLellan, W Robb
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2015
• Subjects: Animals; Cell Differentiation - physiology; Cellular biology; Heart; Heart - physiology; Heart Diseases - physiopathology; Humans; Maturation; Myocytes, Cardiac - physiology; Physiology; Regeneration - physiology; Reviews; Stem cells; Stem Cells - physiology; Tissue engineering
• ISSN: 0031-9333; 1522-1210
• DOI: 10.1152/physrev.00021.2014

After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly. While this debate has energized the field of cardiac regeneration and led to a dramatic increase in our understanding of cardiac growth and repair, it has left much confusion in the field as to the prospects of regenerating the heart. Studies applying modern techniques of genetic lineage tracing and carbon-14 dating have begun to establish limits on the amount of endogenous regeneration after cardiac injury, but the underlying cellular mechanisms of this regeneration remained unclear. These same studies have also revealed an astonishing capacity for cardiac repair early in life that is largely lost with adult differentiation and maturation. Regardless, this renewed focus on cardiac regeneration as a therapeutic goal holds great promise as a novel strategy to address the leading cause of death in the developed world.