Association between e-cigarette use and myocardial infarction: a systematic review and meta-analysis

• Published in: The Egyptian heart journal Vol. 75; no. 1; p. 97
• Main Authors: Ashraf, Muhammad Talal, Shaikh, Asim, Khan, Muhammad Khuzzaim Shakeel, Uddin, Naseer, Kashif, Muhammad Arham bin, Rizvi, Syed Hassan Ahmed, Khalid, Hammad, Sam, Stafford Jude, Sohail, Affan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Analysis; Cardiology; Cardiovascular; Cardiovascular disease; Electronic cigarettes; Marketing research; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Meta-analysis; Myocardial infarction; Myocardial ischemia; Nicotine; Ratios; Smokers; Smoking; Systematic review; Tobacco; Vape; United States > US; Myocardial infarction; Vape; Myocardial ischemia; Cardiology; Cardiovascular; Electronic cigarettes
• ISSN: 2090-911X; 1110-2608; 2090-911X
• DOI: 10.1186/s43044-023-00426-6

Background The popularity of e-cigarettes has risen dramatically over the last few years, particularly among the younger population. Although the use of combustible cigarettes has established evidence to be associated with the development of several adverse cardiopulmonary diseases, the investigations regarding the prospective long-term effects of e-cigarette use on the cardiovascular system have just begun. We set to investigate if there is an association between the history of MI and e-cigarette use among smokers and non-smokers? Methods The current review aims to assess the association of myocardial infarction with e-cigarette consumption. PubMed, Google Scholar, and Cochrane Central Register of Controlled Trials (CENTRAL) were queried up to October 2022 to identify articles assessing the incidence of myocardial infarction among e-cigarette users. Data were meta-analyzed using a random-effects model to derive odds ratios (OR) and 95% confidence intervals. Results Nine studies involving 984,764 patients were included. The mean age of e-cigarette smokers was less than the controls, and female participants dominated the sample size. E-cigarette users were associated with increased odds of MI than non-users [OR = 1.44; 95% CI (1.22, 1.74); P  < 0.0001]. Dual users were also associated with increased odds of MI with large effect when compared to non-users [OR = 4.04; 95% CI (3.40, 4.81); P  < 0.00001]. Conclusions Dual use is associated with an increased risk of MI than e-cigarette use only. Similarly, dual and solely e-cigarette consumption patterns of nicotine delivery are at a higher risk of MI than non-smokers.