Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats

We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar...

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Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 80; no. 4; pp. 735 - 743
Main Authors Han, Xiuqing, Liu, Chunhua, Xue, Yong, Wang, Jingfeng, Xue, Changhu, Yanagita, Teruyoshi, Gao, Xiang, Wang, Yuming
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.04.2016
Subjects
Animals
fatty liver
Gene Expression
Gluconeogenesis
glucose intolerance
Glucose Tolerance Test
Insulin - blood
Insulin Resistance
insulin signaling
lipids
Male
Non-alcoholic Fatty Liver Disease - chemically induced
Non-alcoholic Fatty Liver Disease - physiopathology
Orotic Acid - toxicity
Rats
Rats, Wistar
Signal Transduction
Up-Regulation
glucose intolerance
lipids
fatty liver
insulin signaling
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Summary:We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar rats were fed with or without OA supplementation for 30, 60, and 90 days. The NAFLD group showed increased liver lipid at 30, 60, and 90 days; glucose intolerance was noted at 60 and 90 days. Furthermore, partial liver proteins and gene expressions related to upstream signaling of insulin were decreased. However, the liver glycogen content was elevated, and gluconeogenesis genes expressions were obviously decreased at 90 days. The occurrence of fatty liver preceded insulin resistance in OA-induced NAFLD without the interference of obesity and hyperlipidemia, and hepatic insulin resistance may not play a conclusive role in insulin resistance in this model. Whether fatty liver preceded insulin resistance (IR) or vice versa in a long-term orotic acid-induced NAFLD model without the confounding effects of obesity and hyperlipidemia.
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ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2015.1123608