The Hippo Signaling Pathway in Development and Disease

• Published in: Developmental cell Vol. 50; no. 3; pp. 264 - 282
• Main Authors: Zheng, Yonggang, Pan, Duojia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.08.2019
• Subjects: actomyosin; adherens junction; Animals; cancer; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; cell polarity; cytoskeleton; Exosome Multienzyme Ribonuclease Complex - genetics; Exosome Multienzyme Ribonuclease Complex - metabolism; Gene Expression Regulation, Developmental; growth control; hippo signaling; Humans; mechanotransduction; merlin; Neoplasms - genetics; Neoplasms - metabolism; neurofibromatosis; NF2; oncogene; regeneration; scalloped; Signal Transduction; spectrin; TAZ; TEAD; tissue homeostasis; Transcription Factors - genetics; Transcription Factors - metabolism; tumor suppressor; YAP; yorkie; regeneration; cytoskeleton; mechanotransduction; yorkie; YAP; tumor suppressor; TAZ; oncogene; tissue homeostasis; scalloped; TEAD; merlin; adherens junction; actomyosin; growth control; neurofibromatosis; cancer; spectrin; NF2; cell polarity; hippo signaling

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseas...