The Hippo Signaling Pathway in Development and Disease

• Published in: Developmental cell Vol. 50; no. 3; pp. 264 - 282
• Main Authors: Zheng, Yonggang, Pan, Duojia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.08.2019
• Subjects: actomyosin; adherens junction; Animals; cancer; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; cell polarity; cytoskeleton; Exosome Multienzyme Ribonuclease Complex - genetics; Exosome Multienzyme Ribonuclease Complex - metabolism; Gene Expression Regulation, Developmental; growth control; hippo signaling; Humans; mechanotransduction; merlin; Neoplasms - genetics; Neoplasms - metabolism; neurofibromatosis; NF2; oncogene; regeneration; scalloped; Signal Transduction; spectrin; TAZ; TEAD; tissue homeostasis; Transcription Factors - genetics; Transcription Factors - metabolism; tumor suppressor; YAP; yorkie; regeneration; cytoskeleton; mechanotransduction; yorkie; YAP; tumor suppressor; TAZ; oncogene; tissue homeostasis; scalloped; TEAD; merlin; adherens junction; actomyosin; growth control; neurofibromatosis; cancer; spectrin; NF2; cell polarity; hippo signaling
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2019.06.003

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies. The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.