Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies

Stiff person syndrome (SPS) is a rare neurologic disorder, characterized by muscle rigidity and spasms. Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with the classic form of SPS, while antibodies against amphiphysin are associated with the paraneoplastic form of the disease....

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Bibliographic Details
Published inCase reports in neurology Vol. 12; no. 3; pp. 339 - 347
Main Authors Vacaras, Vitalie, Cucu, Enia Eleonora, Radu, Roxana, Muresanu, Dafin Fior
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 02.10.2020
Karger Publishers
Subjects
Abdomen
anti-amphiphysin
Antibodies
Anxiety
Benzodiazepines
Botulinum toxin
Breast cancer
cancer
Case reports
Disease
Drug dosages
Electromyography
Magnetic resonance imaging
Medical research
Muscle pain
Patients
Single Case – General Neurology
Single Case − General Neurology
stiff person
Stiff person
Anti-amphiphysin
Cancer
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Summary:Stiff person syndrome (SPS) is a rare neurologic disorder, characterized by muscle rigidity and spasms. Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with the classic form of SPS, while antibodies against amphiphysin are associated with the paraneoplastic form of the disease. We present the case of a patient with paraneoplastic SPS, presenting with muscle cramps of lower extremities that progressed to severe muscle rigidity and spasms, associated with a right breast tumor and positive anti-amphiphysin antibodies. Paraneoplastic SPS is a rare neurological disorder, challenging for the physicians both to diagnose and treat.
ISSN:1662-680X
1662-680X
DOI:10.1159/000508942