Laparoscopic versus open distal pancreatectomy: A meta-analysis

• Published in: Asian journal of surgery Vol. 35; no. 1; pp. 1 - 8
• Main Authors: Sui, Cheng-Jun, Li, Bin, Yang, Jia-Mei, Wang, Shuang-Jia, Zhou, Yan-Ming
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 2012; Elsevier
• Subjects: Blood Loss, Surgical - statistics & numerical data; distal pancreatectomy; Humans; laparoscopic distal pancreatectomy; Laparoscopy; Length of Stay - statistics & numerical data; Models, Statistical; Odds Ratio; pancreas; Pancreatectomy - methods; Pancreatectomy - mortality; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - surgery; Recovery of Function; Surgery; Treatment Outcome; distal pancreatectomy; laparoscopic distal pancreatectomy; pancreas
• ISSN: 1015-9584; 0219-3108
• DOI: 10.1016/j.asjsur.2012.04.001

Summary Objective Laparoscopic distal pancreatectomy (LDP) is a minimally invasive surgical technique. The aim of the present study was to evaluate the currently available literature and compare the short-term clinical outcomes of patients who underwent LDP for left-sided pancreatic pathology with patients who underwent traditional open surgery. Methods A literature search was performed to identify and compare studies that reported the clinical outcomes of both LDP and open distal pancreatectomy (ODP). Pooled odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (95% CI) were calculated using either fixed-effects or random-effects models. Results Nineteen nonrandomized controlled studies were identified that matched the selection criteria and reported the clinical outcomes of 1935 patients, of whom 805 underwent LDP and 1130 underwent ODP. Compared with open surgery, reports on laparoscopic resection indicate potentially favorable outcomes in terms of operative blood loss (WMD: -273.11; 95% CI: -404.61 to -141.61), the requirement of a blood transfusion (OR: 0.28; 95% CI: 0.11–0.71), postoperative time until oral intake (WMD: -1.19; 95% CI: -1.87 to -0.50), time to first flatus (WMD: -1.03, 95% CI: -1.93 to -0.12), length of hospital stay (WMD: -3.87, 95% CI: -5.06 to -2.68), and overall morbidity (OR: 0.70, 95% CI: 0.56–0.87). There were no differences in terms of the extent of oncologic clearance and postoperative mortality. Conclusion LDP results in a faster postoperative recovery and a comparable oncologic clearance in comparison with open surgery. Additional large trials are required to delineate the long-term clinical outcomes of patients diagnosed with malignant neoplasms who undergo either of these two surgeries.