"One-Pot" Syntheses of Malondialdehyde Adducts of Nucleosides

Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside add...

Full description

Saved in:
Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 27; no. 2; pp. 103 - 109
Main Authors Szekely, Jozsef, Wang, Hao, Peplowski, Katherine M., Knutson, Charles G., Marnett, Lawrence J., Rizzo, Carmelo J.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.02.2008
Taylor & Francis
Subjects
Biochemistry & Molecular Biology
dG, biomarkers
DNA adducts
DNA Adducts - chemical synthesis
DNA Adducts - chemistry
Life Sciences & Biomedicine
Malondialdehyde
Malondialdehyde - chemistry
Nucleosides - chemical synthesis
Nucleosides - chemistry
Science & Technology
MdG
SITE-SPECIFIC SYNTHESIS
biomarkers
DNA ADDUCT
malondialdehyde
DNA adducts
DEOXYADENOSINE
DEOXYGUANOSINE
OLIGONUCLEOTIDES
Online AccessGet full text

Cover

More Information
Summary:Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.
Bibliography:Medline
NIH RePORTER
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770701795797