A census of the lung: CellCards from LungMAP

• Published in: Developmental cell Vol. 57; no. 1; pp. 112 - 145.e2
• Main Authors: Sun, Xin, Perl, Anne-Karina, Li, Rongbo, Bell, Sheila M., Sajti, Eniko, Kalinichenko, Vladimir V., Kalin, Tanya V., Misra, Ravi S., Deshmukh, Hitesh, Clair, Geremy, Kyle, Jennifer, Crotty Alexander, Laura E., Masso-Silva, Jorge A., Kitzmiller, Joseph A., Wikenheiser-Brokamp, Kathryn A., Deutsch, Gail, Guo, Minzhe, Du, Yina, Morley, Michael P., Valdez, Michael J., Yu, Haoze V., Jin, Kang, Bardes, Eric E., Zepp, Jarod A., Neithamer, Terren, Basil, Maria C., Zacharias, William J., Verheyden, Jamie, Young, Randee, Bandyopadhyay, Gautam, Lin, Sara, Ansong, Charles, Adkins, Joshua, Salomonis, Nathan, Aronow, Bruce J., Xu, Yan, Pryhuber, Gloria, Whitsett, Jeff, Morrisey, Edward E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.01.2022
• Subjects: cell cards; Cell Differentiation - genetics; CellCards; COVID; Databases as Topic; disease; Humans; lung; Lung - cytology; Lung - metabolism; Lung - physiology; LungMAP; regeneration; Regeneration - genetics; repair; resource; single cell; Single-Cell Analysis - methods; lung; COVID; repair; single cell; disease; LungMAP; resource; regeneration; cell cards; CellCards
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2021.11.007

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional properties of existing cell types in lung. The time has come to take a new census. Initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community, we synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication will serve as the starting point of a live, up-to-date guide for lung research at https://www.lungmap.net/cell-cards/. We hope that Lung CellCards will promote the community-wide effort to establish, maintain, and restore respiratory health. •CellCards provides a functional annotation of cell types within the lung•Combines functional and single cell data for a rigorous catalogue of cell lineages•CellCards will evolve to integrate and adapt to new data and emerging technologies In Sun et al., the CellCards initiative integrates functional and emerging single cell genomic datasets for an accurate and evolvable annotation of important cell lineages within the respiratory system. Integration of functional characteristics is critical to properly delineate cell lineages at homeostasis and provide a baseline dataset for comparison to disease states. These CellCards will incorporate new and emerging datasets and technologies as they arise for a better understanding of the impact of acute and chronic disease on lung cell biology.