Toxic effect of Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats

• Published in: Toxicology reports Vol. 5; pp. 38 - 45
• Main Authors: EL-Hak, Heba N.Gad, Moustafa, Abdel Raouf A., Mansour, Samira R.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2018; Elsevier
• Subjects: Biochemical studies; Histopathological studies; Moringa peregrina; Toxicological evaluation; Moringa peregrina; Biochemical studies; Toxicological evaluation; Histopathological studies
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2017.12.012

[Display omitted] •M. peregrina seeds, taken orally, did not show any alternation in rats’ behavioral signals and no mortality.•M. peregrina seeds controlled sugar blood level and lowered hyperlipidaemia by lowering cholesterol and triglyceride levels.•M. peregrina seeds, improved liver and kidney functions by lowering liver enzymes and serum creatinine.•No histopathological changes were detected in the body tested organs.•The intake of different doses of M. peregrina even a high one, exhibit no organ toxicity and are safe for human use. Moringa is multipurpose promising tree particularly for medicinal use. With its high nutritive and pharmaceutical values, every part of the tree is suitable for human consumptions. The use of vegetate parts, seeds or extracts requires toxicological evaluations to prove and verify safety uses before being added to pharmaceutical medicine, or any other products related to human diet. In this study, Moringa peregrina seeds, grown in high elevation mountain in Saint Catherin area, were investigated and evaluated for their toxicity with respect to its topological potential through histological and biochemical studies in Albino rats. Daily doses of 0, 500, 1000 and 2000mg/kg body weight of dry seed of M. peregrina were administered orally to 4 groups of rats for 14days. Biochemical and histopathological results were evaluated by standard methods. Measured biochemical parameters, insulin, albumin, total protein, creatinine, urea, uric acid, Follicle-stimulating hormone, Luteinizing hormone and Testosterone, revealed normal levels compared to control group. However, measured level of blood sugars, cholesterol, triglyceride and liver enzyme, displayed significant decreases. No histopathological changes were detected in the body tested organs. In consequences, intake of different doses of M. peregrina, even high one, exhibit no organ toxicity and are safe for human use.