Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

• Published in: Toxicology reports Vol. 6; pp. 625 - 631
• Main Authors: Seif, Mohamed M., Madboli, Abdel-Naser, Marrez, Diaa A., Aboulthana, Wael M.K.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2019; Elsevier
• Subjects: Cadmium; Chemistry; Histopathology; Kidney; Liver; P. oleracea; Rat; Cadmium; Chemistry; Histopathology; P. oleracea; Rat; Liver; Kidney
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2019.06.013

[Display omitted] •Cadmium (Cd) is a toxic heavy metal widely occurred around the world, particularly in soils, well water and contaminated food/feed.•Cadmium-induced harmful effects on liver/ kidneys function, lipid profile and antioxidant status in experimental rats.•Oral exposure to cadmium caused severe pathological alterations in renal and liver tissues in experimental rats.•Portulaca extract alone or in combination with Cd revered biochemical markers and tissues to the control status. The study was designed to clarify the hapato-nephroprotective effects of purslane ethanolic extract (PEE) against cadmium toxicity. Cadmium (Cd) is a toxic heavy metal. Cd occurs as environmental and food/ feed contamination causing public and animals health hazards. Liver and kidney are the main target organs for acute and chronic cadmium toxicity. Portulaca oleracea is rich in several vitamins, minerals, antioxidant components, and omega-3 fatty acids mainly α-linolenic acid and eicosapentaenoic acid. Results showed significant elevation of the liver and kidney functions, lipid profile and lipid peroxidation. In contrast to the antioxidants enzymatic were greatly decreased. The hepatic and renal tissues showed severe degeneration and necrosis accompanied by severe congestion and multifocal hemorrhages in Cd intoxicated rats. All parameters and tissues showed no changes in rates-treated with both Cd and purslane extract as compared with the control rats. The administration of PEE provided a significantly protection against Cd-induced hepato-nephrotoxicity.