Advances and Applications of Single-Cell Sequencing Technologies

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for studying rare cells and delineating complex populations. Over the past 5 years, SCS methods for DNA and RNA have had a broad impact on many diverse fields of biology, including microbiology, neurobiology, development,...

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Bibliographic Details
Published inMolecular cell Vol. 58; no. 4; pp. 598 - 609
Main Authors Wang, Yong, Navin, Nicholas E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 21.05.2015
Subjects
Animals
Biomedical Research - methods
Biomedical Research - trends
Forecasting
Genomics - methods
High-Throughput Nucleotide Sequencing - methods
Humans
Single-Cell Analysis - methods
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Summary:Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for studying rare cells and delineating complex populations. Over the past 5 years, SCS methods for DNA and RNA have had a broad impact on many diverse fields of biology, including microbiology, neurobiology, development, tissue mosaicism, immunology, and cancer research. In this review, we will discuss SCS technologies and applications, as well as translational applications in the clinic. Wang and Navin provide an overview of what can be achieved with single-cell sequencing, from basic science to translational application in the clinic.
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ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2015.05.005