Induction of Overt Diabetes in KK Mice by Dietary Means

• Published in: Endocrinologia Japonica Vol. 17; no. 6; pp. 477 - 488
• Main Authors: MATSUO, TAKAO, SHINO, AKIO, IWATSUKA, HISASHI, SUZUOKI, ZIRO
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 01.01.1970
• Subjects: Adipose Tissue; Animals; Body Weight; Cholesterol - analysis; Diabetes Mellitus - etiology; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Diet; Epididymis; Fatty Acids - analysis; Fatty Liver - etiology; Glucose Tolerance Test; Glycosuria - etiology; Hyperglycemia - etiology; Islets of Langerhans - pathology; Lipids - analysis; Liver - analysis; Male; Mice; Obesity - etiology; Organ Size

KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became mor...