Induction of Overt Diabetes in KK Mice by Dietary Means
KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became mor...
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Published in | Endocrinologia Japonica Vol. 17; no. 6; pp. 477 - 488 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Japan
The Japan Endocrine Society
01.01.1970
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Subjects | |
Online Access | Get full text |
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Summary: | KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became more prominent with prolonged period of feedig up to 24 weeks. Among them, fatty liver and obesity were also induced in control ICR mice upon feeding semisynthetic diets but the developments were limited in moderate degree and no diabetic symptom developed. These results indicate that the different response to diets in both mice can be attributed to genetic factors. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0013-7219 2185-6370 |
DOI: | 10.1507/endocrj1954.17.477 |