Induction of Overt Diabetes in KK Mice by Dietary Means

KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became mor...

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Published inEndocrinologia Japonica Vol. 17; no. 6; pp. 477 - 488
Main Authors MATSUO, TAKAO, SHINO, AKIO, IWATSUKA, HISASHI, SUZUOKI, ZIRO
Format Journal Article
LanguageEnglish
Published Japan The Japan Endocrine Society 01.01.1970
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Summary:KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became more prominent with prolonged period of feedig up to 24 weeks. Among them, fatty liver and obesity were also induced in control ICR mice upon feeding semisynthetic diets but the developments were limited in moderate degree and no diabetic symptom developed. These results indicate that the different response to diets in both mice can be attributed to genetic factors.
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ISSN:0013-7219
2185-6370
DOI:10.1507/endocrj1954.17.477