Induction of Overt Diabetes in KK Mice by Dietary Means
KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became mor...
Saved in:
| Published in | Endocrinologia Japonica Vol. 17; no. 6; pp. 477 - 488 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Japan Endocrine Society
01.01.1970
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became more prominent with prolonged period of feedig up to 24 weeks. Among them, fatty liver and obesity were also induced in control ICR mice upon feeding semisynthetic diets but the developments were limited in moderate degree and no diabetic symptom developed. These results indicate that the different response to diets in both mice can be attributed to genetic factors. |
|---|---|
| AbstractList | KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became more prominent with prolonged period of feedig up to 24 weeks. Among them, fatty liver and obesity were also induced in control ICR mice upon feeding semisynthetic diets but the developments were limited in moderate degree and no diabetic symptom developed. These results indicate that the different response to diets in both mice can be attributed to genetic factors. |
| Author | SHINO, AKIO MATSUO, TAKAO IWATSUKA, HISASHI SUZUOKI, ZIRO |
| Author_xml | – sequence: 1 fullname: MATSUO, TAKAO organization: Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd – sequence: 2 fullname: SHINO, AKIO organization: Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd – sequence: 3 fullname: IWATSUKA, HISASHI organization: Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd – sequence: 4 fullname: SUZUOKI, ZIRO organization: Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4931786$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdUF1LwzAUDTKZc-4PCEKefOvMbZqkfZSpc2xjL_pc0vRWO7Z2Jqmwf2-kY4j34V6454PDuSaDpm2QkFtgUxBMPWBTtsZuIRPJFNQ0UeqCjGJIRSS5YgMyYgx4pGLIrsjEuS0LI2OpEjYkwyTjoFI5ImrRlJ3xddvQtqKbb7SePtW6QI-O1g1dLum6NkiLY3ij1_ZI16gbd0MuK71zODndMXl_eX6bvUarzXwxe1xFRsSZj9JEMlOUrFI8LrCSLEFTCMwggUoqrYXWHBCUEmVmpMk4QwjROGdCpUqWfEzue9-Dbb86dD7f187gbqcbbDuXpyyNMwARiHFPNLZ1zmKVH2y9D3lzYPlvYfmfwnJQeSgsiO5O7l2xx_IsOdUT8HmPb53XH3jGtfW12eF_S9mv4HxmmE9tA43_ALVzgRU |
| CitedBy_id | crossref_primary_10_1007_BF01212165 crossref_primary_10_1093_jn_105_10_1253 crossref_primary_10_1016_0168_8227_94_90268_2 crossref_primary_10_1016_0026_0495_77_90128_7 crossref_primary_10_1080_08958378_2016_1179373 crossref_primary_10_1248_bpb_28_2152 crossref_primary_10_1002_dmr_5610080302 crossref_primary_10_1016_0168_8227_90_90118_D crossref_primary_10_1016_0024_3205_93_90574_M crossref_primary_10_1152_ajpendo_1996_271_2_E333 crossref_primary_10_1007_BF01225571 crossref_primary_10_1142_S0192415X02000090 crossref_primary_10_1002_dmrr_2572 crossref_primary_10_1007_BF01221994 crossref_primary_10_1007_BF01221995 crossref_primary_10_1007_BF01220641 crossref_primary_10_1007_BF01221998 crossref_primary_10_1152_ajpcell_00450_2009 crossref_primary_10_1093_ecam_nep158 |
| ContentType | Journal Article |
| Copyright | The Japan Endocrine Society |
| Copyright_xml | – notice: The Japan Endocrine Society |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1507/endocrj1954.17.477 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 2185-6370 |
| EndPage | 488 |
| ExternalDocumentID | 10_1507_endocrj1954_17_477 4931786 article_endocrj1954_17_6_17_6_477_article_char_en |
| Genre | Journal Article |
| GroupedDBID | .55 .GJ 3O- 53G 5RE AABQG AAUGY ADBBV AFFNX AI. ALMA_UNASSIGNED_HOLDINGS BAWUL DIK F5P JSF JSH KQ8 OK1 RJT RZJ VH1 X7J X7M ZGI ZXP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c529t-8460cbd0f732bef604ecb5e9141f67aa5aa31e1775d9c6c930e193133057876d3 |
| ISSN | 0013-7219 |
| IngestDate | Fri Jun 28 11:17:26 EDT 2024 Fri Aug 23 03:26:20 EDT 2024 Thu May 23 23:54:28 EDT 2024 Thu Aug 17 20:27:35 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 6 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c529t-8460cbd0f732bef604ecb5e9141f67aa5aa31e1775d9c6c930e193133057876d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/endocrj1954/17/6/17_6_477/_article/-char/en |
| PMID | 4931786 |
| PQID | 80829115 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_80829115 crossref_primary_10_1507_endocrj1954_17_477 pubmed_primary_4931786 jstage_primary_article_endocrj1954_17_6_17_6_477_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1970-01-01 |
| PublicationDateYYYYMMDD | 1970-01-01 |
| PublicationDate_xml | – month: 01 year: 1970 text: 1970-01-01 day: 01 |
| PublicationDecade | 1970 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan |
| PublicationTitle | Endocrinologia Japonica |
| PublicationTitleAlternate | Endocrinol Japon |
| PublicationYear | 1970 |
| Publisher | The Japan Endocrine Society |
| Publisher_xml | – name: The Japan Endocrine Society |
| References | Gerson, T.(1960). Biochem. J., 77, 446. Iwatsuka, H., A. Shino and Z. Suzuoki (1970b). Endocrinol. Japon., 17, 23. Iwatsuka, H., T. Matsuo, A. Shino and Z. Suzuoki (1970a). J. Takeda Res. Lob., 29, 685. Dulin, W. E. and G. C. Gerritsen (1967). Proc. 6th. Congr. Diabetes Fed., (Stockholm). Hackel, D. B., H. E. Lebovitz, L. A. Frohman, E. Miki and K. Schmidt-Nielsen (1967). Metabolism, 16, 1133. Huggett, A. St. G. and D. A. Nixon (1957). Lancet, ii, 368. Batt, R. and P. Mialhe (1966). Nature, 212, 289. Haines, H., D. B. Hackel and K. Schmidt-Nielsen (1965). Am. J. Physiol., 208, 297. Gleason, R. E., V. Lauris and J. S. Soeldner (1967). Diabetologia, 3, 175. Nakamura, M.(1962). Proc. Japan Acad., 38, 348. Hellman, B.(1965). Ann. N. Y. Acad. Sci., 131, 541. Miki, E., A. A. Like, J. Steinke and L. S. Soeldner (1967). Diabetologia, 3, 135. Petersson, B. and B. Hellman (1962). Metabolism, 11, 342. Tsuchida, I.(1966). J. Japan Diabetic Soc., 9, 67.(In Japanese). |
| References_xml | |
| SSID | ssj0000626740 |
| Score | 1.1744974 |
| Snippet | KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow.... |
| SourceID | proquest crossref pubmed jstage |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 477 |
| SubjectTerms | Adipose Tissue Animals Body Weight Cholesterol - analysis Diabetes Mellitus - etiology Diabetes Mellitus - genetics Diabetes Mellitus - pathology Diet Epididymis Fatty Acids - analysis Fatty Liver - etiology Glucose Tolerance Test Glycosuria - etiology Hyperglycemia - etiology Islets of Langerhans - pathology Lipids - analysis Liver - analysis Male Mice Obesity - etiology Organ Size |
| Title | Induction of Overt Diabetes in KK Mice by Dietary Means |
| URI | https://www.jstage.jst.go.jp/article/endocrj1954/17/6/17_6_477/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/4931786 https://search.proquest.com/docview/80829115 |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Endocrinologia Japonica, 1970, Vol.17(6), pp.477-488 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1db9QwLILBAy8IGBPHZx4QL6cezUeb5o2Kga5Utwp2JyZeqrRNpzuJdoLuYfx6nLTNHRuTGC9RZbluG7uO7dgxQq9LLWtBWeXRAnxVXjLuqZpJz6eK1ZJrsOFNHHJxFM5X_NNJcLLd0bXVJV0xK3_9ta7kf7gKMOCrqZK9AWcdUQDANfAXRuAwjP_EY9N3oxxNvsx0Vp4ejrHUdTNNU5MVr42FebjWncmPW2g1hOfGaHxTtaA4bHR9raYbdWbOynW6ehEvj1dZn92XxpmLx8yTIwuN08QBk68GOY3tapYcx4Dk8FffVlma2J2Q5Eu2DTUQaTrSuFDDoD4J88So47SFgYkQeCHru384lSp2RGdXP_KhZ0u_1PK-o98VLR7YxA1tJ2BjjqSbETFzt-4emX1pKXMJhsa1ASr5Do2ciBxo3EZ3KOgkk_2Xfo5cOM4Hx05wf-x3YT5yKLECMm-vvsofZszdDVjyp_p6J8UaK8sH6P7gZeC4F5mH6JZuHqH9uFFd-_0Cv8E279duqOwj4aQItzW2UoRHKcLrBqcpNlKEiws8SBG2UvQYrT5-WL6fe0M7Da8MqOw8sDT9sqj8WjBa6Dr0uS6LQEvCSR0KpQKlGNFEiKCSZVhK5muw7gmDFQG0elixA7TXtI1-gjCpI8YjTmklQ-5XQcELqSNVE8U5oz6doOk4O_lZf2pKfj1LJuhdP4EOd_ijLuOG_QC3OAxTmwhoE_RqnPoc9KPZ9FKNbs9_5pEpHge3Z4IOeo64h3D4OBGFT2_0rs_Qve2f8RztdT_O9QswS7vipRWo30hhhdk |
| link.rule.ids | 315,783,787,27938,27939 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Induction+of+Overt+Diabetes+in+KK+Mice+by+Dietary+Means&rft.jtitle=Endocrinologia+japonica&rft.au=MATSUO%2C+TAKAO&rft.au=SHINO%2C+AKIO&rft.au=IWATSUKA%2C+HISASHI&rft.au=SUZUOKI%2C+ZIRO&rft.date=1970-01-01&rft.issn=0013-7219&rft.eissn=2185-6370&rft.volume=17&rft.issue=6&rft.spage=477&rft.epage=488&rft_id=info:doi/10.1507%2Fendocrj1954.17.477&rft.externalDBID=n%2Fa&rft.externalDocID=10_1507_endocrj1954_17_477 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0013-7219&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0013-7219&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0013-7219&client=summon |