Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic

• Published in: Vaccine Vol. 38; no. 45; pp. 7002 - 7006
• Main Authors: Detoc, Maëlle, Bruel, Sébastien, Frappe, Paul, Tardy, Bernard, Botelho-Nevers, Elisabeth, Gagneux-Brunon, Amandine
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 21.10.2020; Elsevier Limited; Elsevier
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Betacoronavirus - pathogenicity; Clinical trials; Clinical Trials as Topic; Coronavirus Infections - epidemiology; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Coronavirus Infections - psychology; Coronaviruses; COVID-19; COVID-19 Vaccines; Female; France - epidemiology; Health care; Health Personnel; Humans; Immunization; Intention; Life Sciences; Male; Medical personnel; Middle Aged; Pandemics; Pandemics - prevention & control; Patient Acceptance of Health Care - psychology; Patient Safety; Pneumonia, Viral - epidemiology; Pneumonia, Viral - immunology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - psychology; Polls & surveys; Risk perception; SARS-CoV-2; Sex Factors; Surveys and Questionnaires; Vaccination; Vaccination - psychology; Vaccine; Vaccine hesitancy; Vaccines; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; France; COVID-19; SARS-CoV-2; Vaccine; Pandemics; Vaccine hesitancy
• ISSN: 0264-410X; 1873-2518; 0264-410X
• DOI: 10.1016/j.vaccine.2020.09.041

•Nearly 75% of the respondents indicated that they might get COVID-19 vaccine.•48% of the respondents may accept to participate in a COVID-19 vaccine clinical trial.•Healthcare workers were more prone to get vaccinated against COVID-19 than non HCWs. The world is facing the COVID-19 pandemic. The development of a vaccine is challenging. We aimed to determine the proportion of people who intend to get vaccinated against COVID-19 in France or to participate in a vaccine clinical trial. We conducted an anonymous on-line survey from the 26th of March to the 20th of April 2020. Primary endpoints were the intention to get vaccinated against COVID-19 if a vaccine was available or participate in a vaccine clinical trial. Three thousand two hundred and fifty nine individuals answered the survey; women accounted for 67.4% of the respondents. According to their statements, 2.512 participants (77.6%, 95% CI 76.2–79%) will certainly or probably agree to get vaccinated against COVID-19. Older age, male gender, fear about COVID-19, being a healthcare worker and individual perceived risk were associated with COVID-19 vaccine acceptance. Vaccine hesitancy was associated with a decrease in COVID-19 vaccine acceptance. One thousand and five hundred and fifty respondents (47.6% 95% CI 45.9–49.3%) will certainly or probably agree to participate in a COVID-19 vaccine clinical trial. Older age, male gender, being a healthcare worker and individual perceived risk were associated with potential acceptance to participate in a COVID-19 vaccine clinical trial. Vaccine hesitancy was associated with refusal for participation in a COVID-19 vaccine clinical trial. Nearly 75% and 48% of the survey respondents were respectively likely to accept vaccination or participation in a clinical trial against COVID-19. Vaccine hesitancy will be the major barrier to COVID-19 vaccine uptake.