IL-17 signaling in host defense and inflammatory diseases

Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in...

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Bibliographic Details
Published inCellular & molecular immunology Vol. 7; no. 5; pp. 328 - 333
Main Authors Qian, Youcun, Kang, Zizhen, Liu, Caini, Li, Xiaoxia
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2010
Nature Publishing Group
Subjects
Animals
Antibodies
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
Biomedical and Life Sciences
Biomedicine
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammatory diseases
Interleukin 17
Interleukin-17 - immunology
Medical Microbiology
Microbiology
Receptors, Interleukin-17 - immunology
Receptors, Interleukin-17 - metabolism
Review
Signal Transduction
Therapeutic targets
Vaccine
inflammation
interleukin-17
signaling
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Summary:Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2010.27