Hematopoietic Stem Cell Metabolism during Development and Aging

• Published in: Developmental cell Vol. 54; no. 2; pp. 239 - 255
• Main Authors: Nakamura-Ishizu, Ayako, Ito, Keisuke, Suda, Toshio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2020
• Subjects: Aging - physiology; Animals; Cell Differentiation - physiology; Cell Lineage - physiology; Cell Proliferation - physiology; Hematopoiesis - physiology; Hematopoietic Stem Cells - metabolism; Humans

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multipl...