Hematopoietic Stem Cell Metabolism during Development and Aging

• Published in: Developmental cell Vol. 54; no. 2; pp. 239 - 255
• Main Authors: Nakamura-Ishizu, Ayako, Ito, Keisuke, Suda, Toshio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2020
• Subjects: Aging - physiology; Animals; Cell Differentiation - physiology; Cell Lineage - physiology; Cell Proliferation - physiology; Hematopoiesis - physiology; Hematopoietic Stem Cells - metabolism; Humans
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2020.06.029

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism. Metabolic requirements of hematopoietic stem cells (HSCs) and their adaptations to their niches during development have remained largely unaddressed. In this review, Suda and colleagues highlight how mitochondrial metabolism determines HSC fate, focusing on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.