Extracellular galectins as controllers of cytokines in hematological cancer

Galectins and cytokines are both secreted proteins whose levels are prognosis factors for several cancers. Extracellular galectins bind to the glycans decorating glycoproteins and are overproduced in most cancers. Accumulative evidence shows that galectins regulate cytokines during cancer progressio...

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Bibliographic Details
Published inBlood Vol. 132; no. 5; pp. 484 - 491
Main Authors Gordon-Alonso, Monica, Bruger, Annika M., van der Bruggen, Pierre
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 02.08.2018
American Society of Hematology
Subjects
Animals
Cytokines - immunology
Cytokines - metabolism
Extracellular Space - metabolism
Galectins - metabolism
Hematologic Neoplasms - immunology
Hematologic Neoplasms - metabolism
Hematologic Neoplasms - pathology
Humans
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Summary:Galectins and cytokines are both secreted proteins whose levels are prognosis factors for several cancers. Extracellular galectins bind to the glycans decorating glycoproteins and are overproduced in most cancers. Accumulative evidence shows that galectins regulate cytokines during cancer progression. Although galectins alter cytokine function by binding to the glycans decorating cytokines or their receptors, cytokines could also regulate galectin expression and function. This review revises these complex interactions and their clinical impact, particularly in hematological cancers. [Display omitted]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-04-846014