Current issues in chronic graft-versus-host disease

Chronic graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Increased transplantation of older patients and the more frequent use of unrelated donors has led to increased numbers of patients with this pai...

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Bibliographic Details
Published inBlood Vol. 124; no. 3; pp. 374 - 384
Main Authors Socié, Gérard, Ritz, Jerome
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 17.07.2014
American Society of Hematology
Subjects
Advances in Hematopoietic Cell Transplantation
Allografts
B-Lymphocytes - immunology
Chronic Disease
Clinical Trials as Topic
Graft vs Host Disease - etiology
Graft vs Host Disease - physiopathology
Graft vs Host Disease - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Models, Immunological
Prognosis
Review Series
Risk Factors
T-Lymphocytes - immunology
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Summary:Chronic graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Increased transplantation of older patients and the more frequent use of unrelated donors has led to increased numbers of patients with this painful complication. Recent advances have been made in understanding the pathophysiology of chronic GVHD and in establishing precise criteria for diagnosis and classification of disease manifestations. These advances will hopefully pave the way for improving both the prophylaxis and treatment of chronic GVHD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2014-01-514752