The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters
Abstract Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters respon...
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| Published in | Nucleic acids research Vol. 47; no. D1; pp. D625 - D630 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
08.01.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0305-1048 1362-4962 1362-4962 |
| DOI | 10.1093/nar/gky1060 |
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| Abstract | Abstract
Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/. |
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| AbstractList | Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/. Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/.Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/. Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/ . Abstract Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access the wealth of biosynthetic clusters responsible for the production of these compounds by genome mining. antiSMASH is one of the most popular tools in this field. The antiSMASH database provides pre-computed antiSMASH results for many publicly available microbial genomes and allows for advanced cross-genome searches. The current version 2 of the antiSMASH database contains annotations for 6200 full bacterial genomes and 18,576 bacterial draft genomes and is available at https://antismash-db.secondarymetabolites.org/. |
| Author | Weber, Tilmann Blin, Kai de los Santos, Emmanuel L C Medema, Marnix H Pascal Andreu, Victòria Del Carratore, Francesco Lee, Sang Yup |
| AuthorAffiliation | 2 Bioinformatics Group, Wageningen University, Wageningen, Netherlands 5 Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea 3 Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK 1 Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark 4 Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK |
| AuthorAffiliation_xml | – name: 1 Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark – name: 5 Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea – name: 2 Bioinformatics Group, Wageningen University, Wageningen, Netherlands – name: 3 Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK – name: 4 Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK |
| Author_xml | – sequence: 1 givenname: Kai surname: Blin fullname: Blin, Kai organization: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark – sequence: 2 givenname: Victòria surname: Pascal Andreu fullname: Pascal Andreu, Victòria organization: Bioinformatics Group, Wageningen University, Wageningen, Netherlands – sequence: 3 givenname: Emmanuel L C surname: de los Santos fullname: de los Santos, Emmanuel L C organization: Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK – sequence: 4 givenname: Francesco surname: Del Carratore fullname: Del Carratore, Francesco organization: Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK – sequence: 5 givenname: Sang Yup surname: Lee fullname: Lee, Sang Yup organization: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark – sequence: 6 givenname: Marnix H orcidid: 0000-0002-2191-2821 surname: Medema fullname: Medema, Marnix H organization: Bioinformatics Group, Wageningen University, Wageningen, Netherlands – sequence: 7 givenname: Tilmann orcidid: 0000-0002-8260-5120 surname: Weber fullname: Weber, Tilmann email: tiwe@biosustain.dtu.dk organization: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30395294$$D View this record in MEDLINE/PubMed |
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Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In... Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last... |
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| SubjectTerms | Bioinformatica Bioinformatics Database Issue Databases, Genetic Genome, Bacterial Molecular Sequence Annotation Multigene Family Secondary Metabolism - genetics Software |
| Title | The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters |
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