Suppression of TNF-α-Induced Apoptosis by NF-κB

• Published in: Science (American Association for the Advancement of Science) Vol. 274; no. 5288; pp. 787 - 789
• Main Authors: Van Antwerp, Daniel J., Martin, Seamus J., Kafri, Tal, Green, Douglas R., Verma, Inder M.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 01.11.1996; American Association for the Advancement of Science
• Subjects: Ageing, cell death; Annexins; Apoptosis; Biological and medical sciences; Cell death; Cell lines; Cell physiology; Cells; Embryos; Fibroblasts; Fundamental and applied biological sciences. Psychology; Gels; Molecular and cellular biology; Oligonucleotides; Physiological aspects; T lymphocytes; Tumor necrosis factor; Human; Induction; Cytokine; Transcription repressor; Lymphoma; Signal transduction; Regulation(control); Cell line; Mutation; Transcription factor NFκB; Transcription factor; Tumor necrosis factor α; Apoptosis
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.274.5288.787

Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.