Minireview of progress in the structural study of SARS-CoV-2 proteins

• Published in: Current research in microbial sciences Vol. 1; pp. 53 - 61
• Main Authors: Zhu, Guoliang, Zhu, Chunmei, Zhu, Yun, Sun, Fei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2020; Elsevier
• Subjects: COVID-19; Drug-screening; Genome-encoded proteins; Review; SARS-CoV-2; Structure-based screening; ORF; E protein; SARS-CoV; MERS-CoV; 3CLpro; gRNA; COVID-19; SARS-CoV-2; RBD; RdRp; S protein; RBM; Mpro; N protein; HR1; CatB/L; 6-HB; HR2; NSP; Structure-based screening; ACE2; Genome-encoded proteins; RMP; PD; sgRNA; Drug-screening; M protein; RBD, receptor-binding domain; E protein, Envelope protein; Mpro, Main protease; S protein, Spike glycoprotein; NSP, non-structural protein; 3CLpro, 3C-like protease; PD, peptidase domain; gRNA, genomic RNA; N protein, Nucleocapsid protein; SARS-CoV, severe acute respiratory syndrome coronavirus; RMP, The remdesivir monophosphate; 6-HB, six-helix bundle; HR2, heptad repeat 2; HR1, heptad repeat 1; sgRNA, subgenomic RNA; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; RdRp, RNA-dependent RNA polymerase; M protein, Membrane protein; COVID-19, coronavirus disease 2019; RBM, receptor-binding motif; ORF, Open reading frame; MERS-CoV, the Middle Eastern respiratory syndrome coronavirus; ACE2, angiotensin-converting enzyme 2; CatB/L, cysteine proteases-cathepsin B and L
• ISSN: 2666-5174; 2666-5174
• DOI: 10.1016/j.crmicr.2020.06.003

•Major progress has been achieved with regard to the understanding of the phylogeny and genomic organization of SARS-CoV-2.•This review summarized crucial developments in the elucidation of the structure and function of key SARS-CoV-2 proteins.•The molecular details of SARS-CoV-2 infection and replication could improve the effective clinical treatment. A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization, broke out in China and rapidly developed into a global pandemic, with millions of cases and hundreds of thousands of deaths reported globally. The novel coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the etiological agent of COVID-19. On the basis of experience accumulated following previous SARS-CoV and MERS-CoV outbreaks and research, a series of studies have been conducted rapidly, and major progress has been achieved with regard to the understanding of the phylogeny and genomic organization of SARS-CoV-2 in addition its molecular mechanisms of infection and replication. In the present review, we summarized crucial developments in the elucidation of the structure and function of key SARS-CoV-2 proteins, especially the main protease, RNA-dependent RNA polymerase, spike glycoprotein, and nucleocapsid protein. Results of studies on their associated inhibitors and drugs have also been highlighted. [Display omitted]