Dendritic cells and macrophages in the genitourinary tract

Dendritic cells (DCs) and macrophages are antigen-presenting cells (APCs) that are important in innate immune defense as well as in the generation and regulation of adaptive immunity against a wide array of pathogens. The genitourinary (GU) tract, which serves an important reproductive function, is...

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Published inMucosal immunology Vol. 1; no. 6; pp. 451 - 459
Main Authors Iijima, N, Thompson, J M, Iwasaki, A
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2008
Elsevier Limited
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Summary:Dendritic cells (DCs) and macrophages are antigen-presenting cells (APCs) that are important in innate immune defense as well as in the generation and regulation of adaptive immunity against a wide array of pathogens. The genitourinary (GU) tract, which serves an important reproductive function, is constantly exposed to numerous agents of sexually transmitted infections (STIs). To combat these STIs, several subsets of DCs and macrophages are strategically localized within the GU tract. In the female genital mucosa, recruitment and function of these APCs are uniquely governed by sex hormones. This review summarizes the latest advances in our understanding of DCs and macrophages in the GU tract with respect to their subsets, lineage, and function. In addition, we discuss the divergent roles of these cells in immune defense against STIs as well as in maternal tolerance to the fetus.
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ISSN:1933-0219
1935-3456
DOI:10.1038/mi.2008.57