Bilateral Exudative Retinal Detachments Associated with Nivolumab Immunotherapy

A 58-year-old Caucasian female presented to the retina service with a 2-week history of bilateral decrease in vision. She had stage 4 renal cell carcinoma with osseous metastasis and choroidal metastasis for which she has been treated with Nivolumab immunotherapy. Her exudative retinal detachments r...

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Bibliographic Details
Published inCase reports in ophthalmology Vol. 11; no. 3; pp. 523 - 527
Main Authors Ajlan, Radwan S., Luvisi, Joey, Brass, Connor
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.09.2020
Karger Publishers
Subjects
Case Report
Case reports
Cataracts
Edema
exudative retinal detachment
immune checkpoint inhibitors
Immunotherapy
Kidney cancer
Metastasis
Monoclonal antibodies
nivolumab immunotherapy
Retina
Retinal detachment
Retinoblastoma
Steroids
Targeted cancer therapy
Nivolumab immunotherapy
Immune checkpoint inhibitors
Exudative retinal detachment
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Summary:A 58-year-old Caucasian female presented to the retina service with a 2-week history of bilateral decrease in vision. She had stage 4 renal cell carcinoma with osseous metastasis and choroidal metastasis for which she has been treated with Nivolumab immunotherapy. Her exudative retinal detachments resolved after cessation of Nivolumab in association with subtenon steroids (STK) and intravitreal bevacizumab injections. To the best of our knowledge, this is the first report in the literature describing the resolution of Nivolumab-related exudative retinal detachment after early local therapy using STK injections (10 mg), bevacizumab intravitreal injections, and cessation of Nivolumab. We hope by sharing this report to provide new insight into the management of similar patients.
ISSN:1663-2699
1663-2699
DOI:10.1159/000508091