The functions of N6-methyladenosine modification in lncRNAs

Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6...

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Published inGenes & diseases Vol. 7; no. 4; pp. 598 - 605
Main Authors He, Rong-Zhang, Jiang, Jing, Luo, Di-Xian
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.12.2020
Chongqing Medical University
KeAi Communications Co., Ltd
Subjects
Erasers
LncRNA
N6-methyladenosine
Readers
Review
Writers
LncRNA
N6-methyladenosine
Erasers
Writers
Readers
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Summary:Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.
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These authors have contributed equally to this work.
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2020.03.005