Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer

• Published in: Advanced science Vol. 10; no. 3; pp. e2204334 - n/a
• Main Authors: Li, Qinglin, Zhang, Lizhuo, Lang, Jiayan, Tan, Zhuo, Feng, Qingqing, Zhu, Fei, Liu, Guangna, Ying, Zhangguo, Yu, Xuefei, Feng, He, Yi, Heqing, Wen, Qingliang, Jin, Tiefeng, Cheng, Keman, Zhao, Xiao, Ge, Minghua
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc; Wiley
• Subjects: Acids; anaplastic thyroid carcinoma; Animals; Cancer therapies; Cell Line, Tumor; Efficiency; Gene expression; Humans; Iodine; Iodine Radioisotopes - therapeutic use; Lipids; lipid‐peptide‐mRNA nanoparticles; Liposomes; Lymphatic system; Medical prognosis; Mice; Mice, Nude; mRNA delivery; Nanoparticles; Peptides; Protein expression; Proteins; RNA, Messenger; sodium iodide transporter; Statistical significance; Thyroid cancer; Thyroid Carcinoma, Anaplastic - genetics; Thyroid Carcinoma, Anaplastic - metabolism; Thyroid Carcinoma, Anaplastic - therapy; Thyroid Neoplasms - genetics; Thyroid Neoplasms - radiotherapy; Tumors; anaplastic thyroid carcinoma; lipid-peptide-mRNA nanoparticles; mRNA delivery; sodium iodide transporter

Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient delivery of messenger RNA (mRNA) to manipulate protein expression, a lipid‐peptide‐mRNA (LPm) nanoparticle (NP) is developed. The L...