Superoxide Dismutase Activity in Helicobacter pylori—Positive Antral Gastritis in Children

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 23; no. 5; pp. 609 - 613
• Main Authors: Broide, Efrat, Klinowski, Elieser, Varsano, Rina, Eshchar, Jerachmiel, Herbert, Mehrdad, Scapa, Eitan
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott-Raven Publishers 01.12.1996; Lippincott
• Subjects: Adolescent; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Biopsy; Child; Erythrocytes - enzymology; Female; Gastritis - enzymology; Gastritis - microbiology; Helicobacter Infections - enzymology; Helicobacter pylori - isolation & purification; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Pyloric Antrum - enzymology; Stomach - enzymology; Superoxide Dismutase - blood; Superoxide Dismutase - metabolism; Tropical medicine; Human; Spirillales; Enzyme; Spirillaceae; Superoxide dismutase; Gastritis; Result; Infection; Campylobacter infection; Assay; Antrum pyloricum; Relation; Enzymatic activity; Helicobacter pylori; Bacteriosis; Digestive diseases; Bacteria; Oxidoreductases; Lesion; Child; Gastric disease
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/00005176-199612000-00017

SUMMARYReactive oxygen metabolites have been implicated in gastric mucosal injuries. Superoxide dismutase, a scavenger of superoxide radical, is a key enzyme in gastric mucosal protection against several damaging factors. This study was aimed at investigating the relationship of superoxide dismutase activity to Helicobacter pylori—induced antral gastritis in children. Two groups of 11 children each, one positive and the other negative for Helicobacter pylori, were studied. Biopsies from the antrum and corpus were obtained for evaluation of Helicobacter pylori by CLOtest and histology as well as for superoxide dismutase activity (cytochrome c method). Erythrocytic and serum superoxide dismutase levels were determined as well. Superoxide dismutase activity was significantly higher only in the antrum of children with Helicobacter pylori—induced antral gastritis. There was no significant difference in superoxide dismutase activity in the corpus, erythrocytes, or serum of both groups. These findings may suggest a pathogenic relationship between the presence of Helicobacter pylori and oxygen radicals in inducing antral mucosal injury.