Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment

Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard‐risk (SR) or intermediate‐risk (IR) acute lymphoblastic leukemia (ALL). Both naïve and memory B cells were most severely affected and showed slow recovery during the 2‐year follow‐up, while the T‐...

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Published inPediatric blood & cancer Vol. 63; no. 9; pp. 1653 - 1656
Main Authors Koskenvuo, Minna, Ekman, Ilse, Saha, Emmi, Salokannel, Ellinoora, Matomäki, Jaakko, Ilonen, Jorma, Kainulainen, Leena, Arola, Mikko, Lähteenmäki, Päivi Maria
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.09.2016
Wiley Subscription Services, Inc
Subjects
Adolescent
Adult
B cell
B-Lymphocytes - immunology
chemotherapy
Child
Child, Preschool
Complement Pathway, Alternative
Hematology
Humans
immune recovery
Immunity, Humoral
leukemia
Oncology
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
T cell
immune recovery
B cell
leukemia
chemotherapy
T cell
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Summary:Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard‐risk (SR) or intermediate‐risk (IR) acute lymphoblastic leukemia (ALL). Both naïve and memory B cells were most severely affected and showed slow recovery during the 2‐year follow‐up, while the T‐cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine‐preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B‐cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function.
Bibliography:Supplemental Figure 1. The absolute cell counts of different CD8+ T cell subpopulations according to the time presented separately by standard (SR) and intermediate (IR) risk groups.Supplemental Table I. The median peripheral blood cell counts and immunoglobulin levels including the subclasses according to the time (0, 3, 6, 9, 12, 18, and 24 months after cessation of the leukemia treatment) of standard risk (SR) and intermediate risk (IR) children with leukemia.
ArticleID:PBC26047
istex:BDD64A174141734E343330A699EF9015DD695756
ark:/67375/WNG-7Q0PBVLM-Z
Grant sponsor: Foundation of Pediatric Research in Finland; Grant sponsor: Finnish Cancer Society; Grant sponsor: Foundation of Cancer Research of Moikoinen.
Conflict of interest: Nothing to declare.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.26047