New paradigms in clonal evolution: punctuated equilibrium in cancer

• Published in: The Journal of pathology Vol. 240; no. 2; pp. 126 - 136
• Main Authors: Cross, William CH, Graham, Trevor A, Wright, Nicholas A
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2016; Wiley Subscription Services, Inc
• Subjects: Big Bang; cancer; Clonal Evolution; colorectal cancer; gradualism; Humans; Models, Theoretical; Neoplasms - pathology; punctuated equilibrium; punctuated equilibrium; Big Bang; cancer; colorectal cancer; clonal evolution; gradualism

Evolutionary theories are themselves subject to evolution. Clonal evolution – the model that describes the initiation and progression of cancer – is entering a period of profound change, brought about largely by technological developments in genome analysis. A flurry of recent publications, using mo...