New paradigms in clonal evolution: punctuated equilibrium in cancer

Evolutionary theories are themselves subject to evolution. Clonal evolution – the model that describes the initiation and progression of cancer – is entering a period of profound change, brought about largely by technological developments in genome analysis. A flurry of recent publications, using mo...

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Bibliographic Details
Published inThe Journal of pathology Vol. 240; no. 2; pp. 126 - 136
Main Authors Cross, William CH, Graham, Trevor A, Wright, Nicholas A
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.10.2016
Wiley Subscription Services, Inc
Subjects
Big Bang
cancer
Clonal Evolution
colorectal cancer
gradualism
Humans
Models, Theoretical
Neoplasms - pathology
punctuated equilibrium
punctuated equilibrium
Big Bang
cancer
colorectal cancer
clonal evolution
gradualism
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Summary:Evolutionary theories are themselves subject to evolution. Clonal evolution – the model that describes the initiation and progression of cancer – is entering a period of profound change, brought about largely by technological developments in genome analysis. A flurry of recent publications, using modern mathematical and bioinformatics techniques, have revealed both punctuated and neutral evolution phenomena that are poorly explained by the conventional graduated perspectives. In this review, we propose that a hybrid model, inspired by the evolutionary model of punctuated equilibrium, could better explain these recent observations. We also discuss the conceptual changes and clinical implications of variable evolutionary tempos. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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ISSN:0022-3417
1096-9896
DOI:10.1002/path.4757