Breast cancer after bilateral risk-reducing mastectomy

• Published in: Clinical genetics Vol. 79; no. 5; pp. 431 - 437
• Main Authors: Skytte, A-B, Crüger, D, Gerster, M, Lænkholm, A-V, Lang, C, Brøndum-Nielsen, K, Andersen, MK, Sunde, L, Kølvraa, S, Gerdes, A-M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2011; Wiley-Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; BRCA1; BRCA2; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Breast Neoplasms - surgery; Female; Fundamental and applied biological sciences. Psychology; General aspects. Genetic counseling; Genes, BRCA1; Genes, BRCA2; Genetic counseling; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Mastectomy; Mastectomy - methods; Medical genetics; Medical sciences; Middle Aged; Molecular and cellular biology; Mutation; risk; risk reduction; Risk Reduction Behavior; Tumors; Young Adult; Human; risk reduction; Breast disease; Bilateral; Risk; Breast cancer; Malignant tumor; BRCA2; Mammary gland diseases; Reduction; Treatment; Surgery; Risk factor; Mastectomy; Breast; Genetics; BRCA 1; Cancer
• ISSN: 0009-9163; 1399-0004
• DOI: 10.1111/j.1399-0004.2010.01604.x

Skytte A‐B, Crüger D, Gerster M, Lænkholm A‐V, Lang C, Brøndum‐Nielsen K, Andersen MK, Sunde L, Kølvraa S, Gerdes A‐M. Breast cancer after bilateral risk‐reducing mastectomy. This study aims to evaluate the incidence of breast cancer after risk‐reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long‐term follow‐up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk‐reducing bilateral salpingo‐oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post‐mastectomy breast cancer was 0.8% compared with 1.7% in the non‐operated group. Implications of these findings in relation to genetic counseling and future management are discussed.