Immunometabolism: an emerging frontier

• Published in: Nature reviews. Immunology Vol. 11; no. 2; pp. 81 - 83
• Main Authors: Mathis, Diane, Shoelson, Steven E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2011; Nature Publishing Group
• Subjects: 631/250; 631/443/319; 631/443/319/1642/393; Adipokines - metabolism; Alzheimer's disease; Biomedical and Life Sciences; Biomedicine; Body fat; Cardiovascular disease; CD8-Positive T-Lymphocytes - metabolism; Chemokines; Chronic Disease; Chronic diseases; Chronic illnesses; Clinical outcomes; Clinical trials; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; Epidemics; foreword; Genetic aspects; Glucose; Hematopoietic Stem Cells - metabolism; Humans; Immune response; Immune system; Immunology; Inflammation; Inflammation - immunology; Inflammation - metabolism; Ligands; Metabolism; Obesity; Obesity - immunology; Obesity - metabolism; Physiological aspects; Prevention; Proteins; Risk factors; Tumor necrosis factor-TNF; United States; United States > US; Massachusetts
• ISSN: 1474-1733; 1474-1741
• DOI: 10.1038/nri2922

An introduction to immunometabolism: the scope and future opportunities in this emerging field. Immunometabolism is an emerging field of investigation at the interface between the historically distinct disciplines of immunology and metabolism. Accelerating interest in this area is being fuelled by the obesity epidemic and the relatively recent realization that obesity affects the immune system and promotes inflammation, and that obesity-induced inflammation potentially promotes a variety of chronic conditions and diseases. The multilevel interactions between the metabolic and immune systems suggest pathogenic mechanisms that may underlie many of the downstream complications of obesity and offer substantial therapeutic promise.