Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population
Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility....
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Published in | European journal of immunogenetics Vol. 25; no. 4; pp. 317 - 320 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.08.1998
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility. We have examined HLA‐DRB1, C4 and TNF microsatellites in 50 Spanish SLE patients and 48 matched controls. HLA‐DRB1*0301 was increased in patients but did not achieve statistical significance (41% vs. 25.5%). C4A*Q0 was not increased in patients, but C4B*Q0 allele frequency was significantly increased compared with the controls (29% vs. 6%; OR: 6.0). TNF c2 microsatellite allele frequency was also increased in SLE patients. The C4B null allele (C4B*Q0) appears to play an important role in SLE susceptibility in the Spanish population. |
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Bibliography: | ark:/67375/WNG-HVWRG2PG-R istex:1234932EC262005711C0B582E7B9380DC2CF1270 ArticleID:IJI110 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0960-7420 1365-2370 |
DOI: | 10.1046/j.1365-2370.1998.00110.x |