Exploring emotional well-being, spiritual, religious and personal beliefs and telomere length in chronic pain patients-A pilot study with cross-sectional design

• Published in: PloS one Vol. 19; no. 9; p. e0308924
• Main Authors: Rönne-Petersén, Linn, Niemi, Maria, Walach, Harald, Lavebratt, Catharina, Yang, Liu L, Gerdle, Björn, Ghafouri, Bijar, Falkenberg, Torkel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.09.2024; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aging; Anxiety; Biology and Life Sciences; Care and treatment; Chronic illnesses; Chronic pain; Chronic Pain - psychology; Complications and side effects; Correlation; Cross-Sectional Studies; Depression - psychology; Depression, Mental; Diagnosis; Emotions; Enzymes; Female; Health aspects; Health care; Humans; Male; Measurement; Mediation; Medical research; Medicin och hälsovetenskap; Medicine and Health Sciences; Medicine, Experimental; Mental depression; Middle Aged; Mindfulness; Pain; Patient Reported Outcome Measures; Patients; People and places; Pilot Projects; Psychological aspects; Quality of Life; Questionnaires; Rehabilitation; Religion; Risk factors; Social aspects; Social Sciences; Spirituality; Stress; Surveys and Questionnaires; Sweden; Telomerase; Telomerase - genetics; Telomerase - metabolism; Telomere - genetics; Telomeres; Well being; Sweden
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0308924

Living with chronic pain is associated with substantial suffering and high societal costs. Patient reported outcomes (PROM's) and cellular ageing should be considered in pain management. The aim of this study was to explore correlations of PROM's and cellular ageing (telomere length [TL] and telomerase activity [TA]) amongst patients with chronic non-malignant pain. This was an explorative pilot study with cross-sectional design and recruitment was done at two pain rehabilitation facilities in Sweden, with inpatient setting/integrative care and outpatient setting/multimodal care, respectively. Eighty-four patients were enrolled by referral to pain rehabilitation in Sweden. The main outcome measures collected after admission in addition to TL and TA were the following PROMs: Numerical Rating Scale (NRS), Chronic Pain Acceptance Questionnaire (CPAQ), Hospital Anxiety and Depression Scale (HADS), Five Facets Mindfulness Questionnaire (FFMQ), WHO Quality of Life-Spiritual, Religious and Personal Beliefs (WHOQoL-SRPB) and EuroQol 5 Dimensions (EQ-5D). All the PROM's showed evidence of poor overall health status among the participants. TL correlated negatively with HADS score (r = -.219, p = .047) and positively with WHOQoL-SRPB (r = .224, p = .052). TL did not correlate with any of the pain measures. TA correlated positively with pain spread (r = .222, p = .049). A mediation of the direct effect of spiritual well-being on TL by anxiety and depression could be shown (b = 0.008; p = .045). The correlations between TL and SRPB and anxiety and depression suggest some importance of emotional and SRPB dimensions in pain management, with implications for cellular aging, which may warrant further study. Trial registration: ClinicalTrials.gov Identifier: NCT02459639.