Clinical Significance of Preoperative Neutrophil - to - Lymphocyte Ratio in Renal Cell Carcinoma

• Published in: International Brazilian Journal of Urology Vol. 42; no. 4; pp. 678 - 684
• Main Authors: Otunctemur, Alper, Dursun, Murat, Besiroglu, Huseyin, Ozer, Kutan, Horsanali, Ozan, Ozbek, Emin
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Urologia 01.07.2016
• Subjects: Aged; Carcinoma; Carcinoma, Renal Cell - blood; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - surgery; Epithelium; Female; Humans; Kidney Neoplasms - blood; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neoplasm Staging; Neutrophils; Original; Preoperative Care; Prognosis; Renal Cell; Retrospective Studies; Risk Factors; Epithelium; Carcinoma, Renal Cell; Neutrophils
• ISSN: 1677-5538; 1677-6119; 1677-6119; 1677-5538
• DOI: 10.1590/S1677-5538.IBJU.2015.0397

We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma. The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage(T1 + T2) and higher(T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher(G3+G4) too. The best NLR cut off value was 3.01.Two sample t-test or Mann-Whitney U-test used for the continuous variables and a chi-square test or Fisher's exact test used for the categorical variables. Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/ dL (normal less than 0.3), neutrophil count 4,23 ± 1.46/μL, lymphocyte count 1,61 ± 0,61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly correlated with CRP (p<0.0001). And tumor patologic stage (p=0.08), tumor histologic grade (p<0.001) was significantly associated with NLR. We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study.