Cytoreductive nephrectomy and its role in the present-day period of targeted therapy

The beneficial effect of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma in the immunotherapy era was based on two prospective randomized trials. Unfortunately, such evidence does not yet exist in the present-day period of targeted therapy. Despite this, cytore...

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Bibliographic Details
Published inTherapeutic Advances in Urology Vol. 7; no. 5; pp. 275 - 285
Main Author Culp, Stephen H.
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.10.2015
Sage Publications Ltd
SAGE Publishing
Subjects
Kidney cancer
Metastasis
Reviews
targeted therapy
metastatic renal cell carcinoma
cytoreductive nephrectomy
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Summary:The beneficial effect of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma in the immunotherapy era was based on two prospective randomized trials. Unfortunately, such evidence does not yet exist in the present-day period of targeted therapy. Despite this, cytoreductive nephrectomy remains integral in the multimodal management of patients with metastatic renal cell carcinoma. Multiple retrospective studies as well as data from prospective studies examining targeted therapy support the continued use of cytoreductive nephrectomy in the properly selected patient. Ongoing studies will hopefully fine-tune the role and timing of cytoreductive nephrectomy in the context of targeted therapy.
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ISSN:1756-2872
1756-2880
DOI:10.1177/1756287215585501