The Role of the Transcription Factor EGR1 in Cancer

Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 11; p. 642547
Main Authors Wang, Bin, Guo, Hanfei, Yu, Hongquan, Chen, Yong, Xu, Haiyang, Zhao, Gang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.03.2021
Subjects
angiogenesis
apoptosis
cancer
EGR1
invasion
Oncology
proliferation
EGR1
invasion
proliferation
metastasis
angiogenesis
migration
apoptosis
cancer
Online AccessGet full text

Cover

Abstract Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.
AbstractList Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.
Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.
Author Yu, Hongquan
Chen, Yong
Xu, Haiyang
Zhao, Gang
Guo, Hanfei
Wang, Bin
AuthorAffiliation 1 Department of Neurosurgery, The First Hospital of Jilin University , Changchun , China
2 Cancer Center, The First Hospital of Jilin University , Changchun , China
AuthorAffiliation_xml – name: 1 Department of Neurosurgery, The First Hospital of Jilin University , Changchun , China
– name: 2 Cancer Center, The First Hospital of Jilin University , Changchun , China
Author_xml – sequence: 1
  givenname: Bin
  surname: Wang
  fullname: Wang, Bin
– sequence: 2
  givenname: Hanfei
  surname: Guo
  fullname: Guo, Hanfei
– sequence: 3
  givenname: Hongquan
  surname: Yu
  fullname: Yu, Hongquan
– sequence: 4
  givenname: Yong
  surname: Chen
  fullname: Chen, Yong
– sequence: 5
  givenname: Haiyang
  surname: Xu
  fullname: Xu, Haiyang
– sequence: 6
  givenname: Gang
  surname: Zhao
  fullname: Zhao, Gang
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33842351$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1LJDEQxcPi4vd9T9JHLzOb704uggzqCoIgc9hbSKcrGulJxqRH8L83vaOiC-aSolLv98KrA7QTUwSEfhE8Z0zp3z5FN6eYkrnkVPD2B9qnlPGZ5uzvzqd6Dx2X8ojrkQITzHbRXtVzygTZR2z5AM1dGqBJvhlrvcw2FpfDegwpNpfWjSk3F1d3pAmxWdjoIB-hn94OBY7f7kO0vLxYLv7Mbm6vrhfnNzMnqBpnvlWqrx91XBPfYdKyjnPaaQUES-oE5pLoFlxrnWwJcxYkZ9hJTMFLAHaIrrfYPtlHs85hZfOLSTaYf42U743NY3ADGM19TwShQhHLqe06r5SQvWDMU9s7VllnW9Z6062gdxDHbIcv0K8vMTyY-_RsFKa8xlYBp2-AnJ42UEazCsXBMNgIaVMMFYQoLTWZvE4-e32YvIdeB-R2wOVUSgZvXBjtlHe1DoMheJrVZlqwmRZstguuQvyf8J39reQV2zWmgA
CitedBy_id crossref_primary_10_1038_s41598_024_52148_7
crossref_primary_10_1021_acscentsci_3c01169
crossref_primary_10_3389_fcell_2021_756616
crossref_primary_10_1007_s10555_024_10204_8
crossref_primary_10_3390_genes13071174
crossref_primary_10_3390_ijms222011151
crossref_primary_10_3390_ijms23094930
crossref_primary_10_3390_ijms25158086
crossref_primary_10_1007_s10753_023_01922_2
crossref_primary_10_1002_mco2_582
crossref_primary_10_1177_11779322241281652
crossref_primary_10_1038_s41467_025_57795_6
crossref_primary_10_1021_acsomega_3c06610
crossref_primary_10_3390_md22010026
crossref_primary_10_26508_lsa_202201639
crossref_primary_10_3390_foods11233848
crossref_primary_10_3390_ijms242115922
crossref_primary_10_3390_ijms241814375
crossref_primary_10_1021_acs_est_3c02016
crossref_primary_10_1093_procel_pwae032
crossref_primary_10_1007_s12010_024_05112_0
crossref_primary_10_3390_cells12040606
crossref_primary_10_3390_ijms23084174
crossref_primary_10_3389_fcell_2022_1003030
crossref_primary_10_3389_fimmu_2023_1270493
crossref_primary_10_3390_cells13231952
crossref_primary_10_3390_cells12141820
crossref_primary_10_3390_biom14070738
crossref_primary_10_1038_s44161_024_00493_1
crossref_primary_10_1007_s43188_024_00255_y
crossref_primary_10_1186_s12885_024_12005_2
crossref_primary_10_18632_aging_205408
crossref_primary_10_3390_cancers15072163
crossref_primary_10_1038_s41467_023_38265_3
crossref_primary_10_1021_acs_jafc_3c08403
crossref_primary_10_3390_ijerph21081087
crossref_primary_10_3390_nu16132152
crossref_primary_10_1007_s12672_024_01611_y
crossref_primary_10_1038_s41467_023_40271_4
crossref_primary_10_3389_fmolb_2022_834814
crossref_primary_10_1002_eji_202350958
crossref_primary_10_18632_aging_205920
crossref_primary_10_1111_febs_17324
crossref_primary_10_3389_fgene_2024_1414717
crossref_primary_10_1155_2022_2942633
crossref_primary_10_1242_jcs_261825
crossref_primary_10_1002_1873_3468_14407
crossref_primary_10_1152_ajplung_00413_2022
crossref_primary_10_24884_1607_4181_2022_29_1_37_45
crossref_primary_10_1186_s12885_024_13290_7
crossref_primary_10_1186_s13567_023_01239_w
crossref_primary_10_1007_s10528_023_10433_6
crossref_primary_10_1084_jem_20220681
crossref_primary_10_1038_s41598_024_65373_x
crossref_primary_10_1186_s13046_024_02957_5
crossref_primary_10_26508_lsa_202402641
crossref_primary_10_3390_ijms25105474
crossref_primary_10_32604_or_2024_056039
crossref_primary_10_1038_s41421_023_00521_7
crossref_primary_10_1111_bph_16249
crossref_primary_10_3389_fbioe_2022_1052252
crossref_primary_10_3390_ijms26010147
crossref_primary_10_2147_IJGM_S353484
crossref_primary_10_1038_s41420_021_00668_w
crossref_primary_10_3389_fopht_2023_1245891
crossref_primary_10_1038_s42003_025_07531_z
crossref_primary_10_1080_01616412_2023_2176633
crossref_primary_10_1371_journal_pone_0294868
crossref_primary_10_1002_adtp_202400125
crossref_primary_10_1371_journal_pbio_3002034
crossref_primary_10_3389_freae_2024_1423454
crossref_primary_10_1186_s13293_025_00688_6
crossref_primary_10_2174_0929867330666230331101458
crossref_primary_10_1038_s41419_024_06586_w
crossref_primary_10_1186_s13293_023_00557_0
crossref_primary_10_3390_ncrna10010002
crossref_primary_10_1134_S0026893324700389
crossref_primary_10_3390_ijms222111760
crossref_primary_10_3390_ijms241814295
crossref_primary_10_1038_s41388_023_02891_4
crossref_primary_10_3390_ijms25115956
crossref_primary_10_1080_19490976_2022_2089003
crossref_primary_10_1126_scitranslmed_adk5005
crossref_primary_10_3389_fvets_2022_1042445
crossref_primary_10_1126_sciadv_adj7706
crossref_primary_10_1177_09636897231193073
crossref_primary_10_1177_19476035211053824
crossref_primary_10_1002_cam4_70521
crossref_primary_10_3389_fimmu_2023_1331491
crossref_primary_10_1155_2022_3144742
crossref_primary_10_3390_cimb47020098
crossref_primary_10_1007_s13402_024_01014_9
crossref_primary_10_3892_or_2023_8579
crossref_primary_10_3390_cells11142160
crossref_primary_10_3390_life15020159
crossref_primary_10_1007_s10528_024_10679_8
crossref_primary_10_1111_cas_16086
crossref_primary_10_3892_mmr_2022_12646
crossref_primary_10_1002_adma_202404880
crossref_primary_10_1093_stmcls_sxae027
crossref_primary_10_2147_JIR_S350421
crossref_primary_10_1186_s12882_024_03734_4
crossref_primary_10_1186_s12967_023_04043_4
crossref_primary_10_2147_JIR_S498740
crossref_primary_10_3390_cancers16071319
crossref_primary_10_1126_science_abg5601
crossref_primary_10_1186_s12864_023_09681_y
crossref_primary_10_1111_acel_13742
crossref_primary_10_2147_JIR_S489087
crossref_primary_10_3390_genes15040426
crossref_primary_10_3390_ijerph18189519
Cites_doi 10.1038/ncb1201-1124
10.3892/ol.2016.4962
10.2147/OTT.S192061
10.1007/978-1-4939-8922-5_9
10.1158/0008-5472.CAN-07-6496
10.1158/0008-5472.CAN-05-2732
10.5483/BMBRep.2011.44.7.452
10.1016/0092-8674(88)90485-0
10.1002/hep.28773
10.1186/s13018-018-0826-x
10.1172/JCI1404
10.3892/ol.2017.6375
10.23736/S0390-5616.20.05107-3
10.1016/j.bbrc.2008.09.094
10.1016/j.lungcan.2015.01.009
10.3892/ijo.18.4.863
10.2174/1568009043481704
10.1182/blood-2009-03-210526
10.1158/0008-5472.CAN-07-5222
10.1530/JME-12-0154
10.1158/1535-7163.MCT-19-0839
10.1038/s41598-017-18101-7
10.1073/pnas.2628034100
10.1111/j.1349-7006.2005.00105.x
10.1210/me.2006-0392
10.1186/ar2595
10.5483/BMBRep.2020.53.6.290
10.1016/j.jnutbio.2015.02.008
10.1007/s11010-006-9392-3
10.1242/jcs.048272
10.1071/RD12380
10.1038/sj.cgt.7701103
10.1007/s43032-020-00392-3
10.1016/j.canlet.2015.10.021
10.1038/onc.2012.127
10.1111/cpr.12922
10.3389/fimmu.2018.00211
10.1007/s10620-012-2356-4
10.1128/MCB.19.6.3977
10.1074/jbc.M511079200
10.3892/or.19.2.517
10.1200/JCO.2005.08.127
10.1038/sj.cdd.4402029
10.1007/s11010-013-1593-y
10.1016/j.bbrc.2017.07.016
10.1002/jcp.22445
10.1186/s40169-017-0140-y
10.1371/journal.pone.0115170
10.1016/j.prp.2013.08.001
10.1080/10428190802588352
10.1038/sj.onc.1202696
10.18632/oncotarget.13809
10.4161/cbt.6.7.4477
10.1158/0008-5472.CAN-05-1830
10.1007/s10456-011-9246-9
10.1074/jbc.M008454200
10.1016/j.celrep.2019.04.101
10.1007/s10495-006-0576-9
10.1074/jbc.272.32.20131
10.1182/blood-2009-09-241802
10.1016/j.phrs.2016.12.029
10.1016/j.jdermsci.2013.08.002
10.1177/1947601911431885
10.1158/2159-8290.CD-16-0647
10.1016/j.cellsig.2014.06.007
10.1074/jbc.272.52.33056
10.1186/1471-2199-15-14
10.1186/s12885-019-6014-5
10.3233/CBM-161710
10.1038/s41388-019-0873-8
10.1186/s13046-019-1054-x
10.1038/nm905
10.1074/jbc.274.46.32795
10.1158/1078-0432.CCR-04-2071
10.1371/journal.pone.0182422
10.1124/jpet.107.126193
10.1038/sj.emboj.7601213
10.7314/APJCP.2015.16.9.4137
10.1038/onc.2017.359
10.1016/S0021-9258(19)85286-9
10.5483/BMBRep.2013.46.2.202
10.2217/fon.09.67
10.1111/j.1742-4658.2009.07542.x
10.1097/CAD.0000000000000501
10.1038/s41598-020-66236-x
10.2353/ajpath.2010.091164
10.3892/ijo.2016.3666
10.1016/j.canlet.2008.04.045
10.1271/bbb.70103
10.1016/S0166-2236(98)01343-5
10.1002/mc.20454
10.1016/j.canlet.2013.12.001
ContentType Journal Article
Copyright Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao.
Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao 2021 Wang, Guo, Yu, Chen, Xu and Zhao
Copyright_xml – notice: Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao.
– notice: Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao 2021 Wang, Guo, Yu, Chen, Xu and Zhao
DBID AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.3389/fonc.2021.642547
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals (ODIN)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
CrossRef
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2234-943X
ExternalDocumentID oai_doaj_org_article_94fd1512581a42abbf8856d533f2adc3
PMC8024650
33842351
10_3389_fonc_2021_642547
Genre Journal Article
Review
GrantInformation_xml – fundername: Natural Science Foundation of Jilin Province
  grantid: 20200201469JC
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EBS
EJD
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
OK1
PGMZT
RNS
RPM
IAO
IEA
IHR
IHW
IPNFZ
NPM
RIG
7X8
5PM
ID FETCH-LOGICAL-c528t-f788d389c491fb0173b442b98e1062c5046197ec7ac6713cae6430c602ef6ee3
IEDL.DBID M48
ISSN 2234-943X
IngestDate Wed Aug 27 00:26:31 EDT 2025
Thu Aug 21 18:33:12 EDT 2025
Fri Jul 11 15:14:47 EDT 2025
Thu Jan 02 22:57:12 EST 2025
Tue Jul 01 04:38:38 EDT 2025
Thu Apr 24 23:04:59 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords EGR1
invasion
proliferation
metastasis
angiogenesis
migration
apoptosis
cancer
Language English
License Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c528t-f788d389c491fb0173b442b98e1062c5046197ec7ac6713cae6430c602ef6ee3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Edited by: Isacco Ferrarini, Brown University, United States
Reviewed by: Yao Tong, The Scripps Research Institute, United States; Xiang Zhao, Huazhong University of Science and Technology, China
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fonc.2021.642547
PMID 33842351
PQID 2511896913
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_94fd1512581a42abbf8856d533f2adc3
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8024650
proquest_miscellaneous_2511896913
pubmed_primary_33842351
crossref_citationtrail_10_3389_fonc_2021_642547
crossref_primary_10_3389_fonc_2021_642547
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-03-24
PublicationDateYYYYMMDD 2021-03-24
PublicationDate_xml – month: 03
  year: 2021
  text: 2021-03-24
  day: 24
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in oncology
PublicationTitleAlternate Front Oncol
PublicationYear 2021
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Liu (B68) 2008; 377
Shimoyamada (B30) 2010; 177
Sperandio (B45) 2009; 48
Yeo (B39) 2020; 53
Cheng (B29) 2013; 32
Maeda (B87) 2015
Sun (B89) 2017; 14
Shan (B64) 2015; 16
Ma (B13) 2020; 54
Wang (B56) 2015; 26
Ahmed (B79) 2004; 4
Mayer (B90) 2009; 122
Rockel (B7) 2009; 11
Lim (B81) 2007; 12
Chen (B38) 2016; 64
Wang (B94) 2014; 26
Krones-Herzig (B61) 2003; 100
Kim (B65) 2017; 28
Das (B78) 2001; 276
Schwachtgen (B26) 1998; 101
Lucerna (B71) 2006; 66
Park (B24) 2016; 12
Xiao (B73) 2015; 8
Kim (B10) 2011; 44
Wang (B85) 2005; 96
Jeong (B6) 2013; 72
Ryu (B18) 2017; 8
Kuo (B28) 2011; 226
Shin (B63) 2013
Thiel (B82) 2017; 117
Chen (B20) 2020; 28
Zhao (B74) 2008; 68
Kumbrink (B96) 2005; 280
O’Donovan (B95) 1999; 22
Ferraro (B86) 2005; 23
Nair (B59) 1997; 272
Marignol (B3) 2007; 6
Fahmy (B48) 2003; 9
Kim (B66) 2007; 71
Spasevska (B80) 2020; 19
Schmidt (B16) 2019; 27
Grotegut (B37) 2006; 25
Du (B19) 2020
Brown (B47) 2012; 15
Pagel (B4) 2011; 48
Yoon (B51) 2014; 9
Zhong (B88) 2017; 19
Yu (B60) 2007; 14
Knudsen (B22) 2020; 10
Feng (B23) 2019; 19
Zhao (B75) 2008; 270
Spencer (B76) 1999; 19
Shin (B53) 2008; 19
Gabriel (B11) 2016; 49
Wang (B42) 2019; 38
Chen (B54) 2007; 323
Chen (B58) 2010; 115
Virolle (B55) 2001; 3
Li (B12) 2019; 38
Yang (B44) 2014; 26
Gitenay (B33) 2009; 5
Johnson (B34) 2007; 301
Lawson (B91) 2007; 21
Suda (B49) 2017; 12
Ahmed (B52) 1997; 272
Calogero (B15) 2001; 7
Kundumani-Sridharan (B46) 2010; 115
Xiao (B27) 2005; 65
Snyder (B92) 2013; 50
Wan (B36) 2017; 7
Wu (B40) 2017; 7
Wang (B72) 2018; 37
Liu (B70) 2014; 15
Wu (B21) 2018; 9
Shi (B84) 2019; 12
Myung (B14) 2013; 209
de Belle (B17) 1999; 18
Naoum (B77) 2017; 6
Sun (B43) 2013; 58
Shi (B83) 2019; 1895
Park (B41) 2016; 370
Bickenbach (B2) 2008; 15
Shin (B9) 2017; 491
Pan (B57) 2010; 277
Cao (B5) 1993; 268
Gregg (B32) 2011; 2
Sheng (B50) 2018; 13
Huang (B69) 2006; 3
Ji (B31) 2014; 346
Yaari (B35) 2005; 11
Liu (B67) 2009; 50
Sukhatme (B1) 1988; 53
Liu (B25) 2001; 18
Choi (B62) 2008; 68
Cui (B93) 1999; 274
Vaish (B8) 2013; 378
References_xml – volume: 3
  year: 2001
  ident: B55
  article-title: The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1201-1124
– volume: 12
  year: 2016
  ident: B24
  article-title: Expression of early growth response gene-1 in precancerous lesions of gastric cancer
  publication-title: Oncol Lett
  doi: 10.3892/ol.2016.4962
– volume: 12
  year: 2019
  ident: B84
  article-title: GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status
  publication-title: OncoTargets Ther
  doi: 10.2147/OTT.S192061
– volume: 1895
  year: 2019
  ident: B83
  article-title: Resveratrol-Responsive CArG Elements from the Egr-1 Promoter for the Induction of GADD45α to Arrest the G2/M Transition
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-4939-8922-5_9
– volume: 68
  year: 2008
  ident: B74
  article-title: Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-6496
– volume: 66
  year: 2006
  ident: B71
  article-title: Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-2732
– volume: 44
  year: 2011
  ident: B10
  article-title: Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells
  publication-title: BMB Rep
  doi: 10.5483/BMBRep.2011.44.7.452
– volume: 53
  start-page: 37
  year: 1988
  ident: B1
  article-title: A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
  publication-title: Cell
  doi: 10.1016/0092-8674(88)90485-0
– volume: 64
  year: 2016
  ident: B38
  article-title: Angiopoietin-like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma
  publication-title: Hepatol (Baltimore Md)
  doi: 10.1002/hep.28773
– volume: 13
  start-page: 125
  year: 2018
  ident: B50
  article-title: Egr-1 increases angiogenesis in cartilage via binding Netrin-1 receptor DCC promoter
  publication-title: J Orthop Surg Res
  doi: 10.1186/s13018-018-0826-x
– volume: 101
  year: 1998
  ident: B26
  article-title: Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway
  publication-title: J Clin Invest
  doi: 10.1172/JCI1404
– volume: 14
  year: 2017
  ident: B89
  article-title: Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients
  publication-title: Oncol Lett
  doi: 10.3892/ol.2017.6375
– year: 2020
  ident: B19
  article-title: Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1
  publication-title: J Neurosurg Sci
  doi: 10.23736/S0390-5616.20.05107-3
– volume: 377
  year: 2008
  ident: B68
  article-title: LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2008.09.094
– volume: 8
  year: 2015
  ident: B73
  article-title: Clinicopathological significance of NGX6 expression in breast cancer and its relationship to angiogenesis
  publication-title: Int J Clin Exp Med
– year: 2015
  ident: B87
  article-title: CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2015.01.009
– volume: 7
  year: 2001
  ident: B15
  article-title: The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas
  publication-title: Clin Cancer Res
– volume: 18
  year: 2001
  ident: B25
  article-title: Physical interaction between p53 and primary response gene Egr-1
  publication-title: Int J Oncol
  doi: 10.3892/ijo.18.4.863
– volume: 4
  start-page: 43
  year: 2004
  ident: B79
  article-title: Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors
  publication-title: Curr Cancer Drug Targets
  doi: 10.2174/1568009043481704
– volume: 115
  start-page: 61
  year: 2010
  ident: B58
  article-title: Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma
  publication-title: Blood
  doi: 10.1182/blood-2009-03-210526
– volume: 68
  year: 2008
  ident: B62
  article-title: p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5222
– volume: 50
  year: 2013
  ident: B92
  article-title: Interplay between EGR1 and SP1 is critical for 13-cis retinoic acid-mediated transcriptional repression of angiotensin type 1A receptor
  publication-title: J Mol Endocrinol
  doi: 10.1530/JME-12-0154
– volume: 19
  year: 2020
  ident: B80
  article-title: Calcium Channel Blockers Impair the Antitumor Activity of Anti-CD20 Monoclonal Antibodies by Blocking EGR-1 Induction
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-19-0839
– volume: 7
  start-page: 17753
  year: 2017
  ident: B40
  article-title: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-18101-7
– volume: 100
  year: 2003
  ident: B61
  article-title: Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2628034100
– volume: 96
  year: 2005
  ident: B85
  article-title: Cisplatin-controlled p53 gene therapy for human non-small cell lung cancer xenografts in athymic nude mice via the CArG elements
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2005.00105.x
– volume: 21
  year: 2007
  ident: B91
  article-title: Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2
  publication-title: Mol Endocrinol (Baltimore Md)
  doi: 10.1210/me.2006-0392
– volume: 11
  start-page: R8
  year: 2009
  ident: B7
  article-title: Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2595
– volume: 53
  year: 2020
  ident: B39
  article-title: Transcription factor EGR-1 transactivates the MMP1 gene promoter in response to TNFα in HaCaT keratinocytes
  publication-title: BMB Rep
  doi: 10.5483/BMBRep.2020.53.6.290
– volume: 48
  year: 2011
  ident: B4
  article-title: Early growth response 1–a transcription factor in the crossfire of signal transduction cascades
  publication-title: Indian J Biochem Biophys
– volume: 26
  start-page: 797
  year: 2015
  ident: B56
  article-title: EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2015.02.008
– volume: 301
  start-page: 13
  year: 2007
  ident: B34
  article-title: Estrogen-dependent growth and estrogen receptor (ER)-alpha concentration in T47D breast cancer cells are inhibited by VACM-1, a cul 5 gene
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-006-9392-3
– volume: 122
  year: 2009
  ident: B90
  article-title: Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors
  publication-title: J Cell Sci
  doi: 10.1242/jcs.048272
– volume: 26
  year: 2014
  ident: B94
  article-title: The novel porcine gene early growth response 4 (Egr4) is differentially expressed in the ovaries of Erhualian and Pietrain pigs
  publication-title: Reprod Fertil Dev
  doi: 10.1071/RD12380
– volume: 15
  year: 2008
  ident: B2
  article-title: Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy
  publication-title: Cancer Gene Ther
  doi: 10.1038/sj.cgt.7701103
– volume: 28
  year: 2020
  ident: B20
  article-title: EGR1 Overexpression Inhibits the Occurrence of Preeclampsia by Binding to MicroRNA-574 Promoter and Upregulating GAB1
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1007/s43032-020-00392-3
– volume: 370
  year: 2016
  ident: B41
  article-title: Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.10.021
– volume: 32
  year: 2013
  ident: B29
  article-title: Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells
  publication-title: Oncogene
  doi: 10.1038/onc.2012.127
– volume: 54
  start-page: e12922
  year: 2020
  ident: B13
  article-title: EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer
  publication-title: Cell Proliferation
  doi: 10.1111/cpr.12922
– volume: 3
  start-page: 71
  year: 2006
  ident: B69
  article-title: Early Growth Response-1 Suppresses Human Fibrosarcoma Cell Invasion and Angiogenesis
  publication-title: Cancer Genomics Proteomics
– volume: 9
  year: 2018
  ident: B21
  article-title: Pseudomonas aeruginosaBeta-Defensin 2 and 3 Promote Bacterial Clearance of by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00211
– volume: 58
  year: 2013
  ident: B43
  article-title: Egr-1 promotes cell proliferation and invasion by increasing β-catenin expression in gastric cancer
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-012-2356-4
– volume: 19
  year: 1999
  ident: B76
  article-title: Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.19.6.3977
– volume: 280
  year: 2005
  ident: B96
  article-title: Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M511079200
– volume: 19
  year: 2008
  ident: B53
  article-title: Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells
  publication-title: Oncol Rep
  doi: 10.3892/or.19.2.517
– volume: 23
  year: 2005
  ident: B86
  article-title: EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2005.08.127
– volume: 14
  year: 2007
  ident: B60
  article-title: A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
  publication-title: Cell Death Differ
  doi: 10.1038/sj.cdd.4402029
– volume: 378
  start-page: 47
  year: 2013
  ident: B8
  article-title: NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-013-1593-y
– volume: 491
  year: 2017
  ident: B9
  article-title: γ-Oryzanol suppresses COX-2 expression by inhibiting reactive oxygen species-mediated Erk1/2 and Egr-1 signaling in LPS-stimulated RAW264.7 macrophages
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2017.07.016
– volume: 226
  year: 2011
  ident: B28
  article-title: CXCL5/ENA78 increased cell migration and epithelial-to-mesenchymal transition of hormone-independent prostate cancer by early growth response-1/snail signaling pathway
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.22445
– volume: 6
  start-page: 11
  year: 2017
  ident: B77
  article-title: Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs
  publication-title: Clin Trans Med
  doi: 10.1186/s40169-017-0140-y
– volume: 9
  start-page: e115170
  year: 2014
  ident: B51
  article-title: Egr-1 activation by cancer-derived extracellular vesicles promotes endothelial cell migration via ERK1/2 and JNK signaling pathways
  publication-title: PloS One
  doi: 10.1371/journal.pone.0115170
– volume: 209
  year: 2013
  ident: B14
  article-title: Expression of early growth response-1 in human gastric cancer and its relationship with tumor cell behaviors and prognosis
  publication-title: Pathol Res Pract
  doi: 10.1016/j.prp.2013.08.001
– volume: 50
  year: 2009
  ident: B67
  article-title: Thalidomide inhibits leukemia cell invasion and migration by upregulation of early growth response gene 1
  publication-title: Leuk Lymphoma
  doi: 10.1080/10428190802588352
– volume: 18
  year: 1999
  ident: B17
  article-title: p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1202696
– volume: 8
  year: 2017
  ident: B18
  article-title: Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13809
– volume: 6
  year: 2007
  ident: B3
  article-title: Radiation to control transgene expression in tumors
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.6.7.4477
– volume: 65
  year: 2005
  ident: B27
  article-title: Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-1830
– volume: 15
  start-page: 99
  year: 2012
  ident: B47
  article-title: MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway
  publication-title: Angiogenesis
  doi: 10.1007/s10456-011-9246-9
– volume: 276
  year: 2001
  ident: B78
  article-title: Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M008454200
– volume: 27
  start-page: 2493
  year: 2019
  ident: B16
  article-title: The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2019.04.101
– volume: 12
  year: 2007
  ident: B81
  article-title: NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells
  publication-title: Apoptosis
  doi: 10.1007/s10495-006-0576-9
– volume: 272
  year: 1997
  ident: B59
  article-title: Early growth response-1-dependent apoptosis is mediated by p53
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.32.20131
– volume: 115
  year: 2010
  ident: B46
  article-title: 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression
  publication-title: Blood
  doi: 10.1182/blood-2009-09-241802
– volume: 117
  year: 2017
  ident: B82
  article-title: Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2016.12.029
– volume: 72
  year: 2013
  ident: B6
  article-title: ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2013.08.002
– volume: 2
  year: 2011
  ident: B32
  article-title: Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells
  publication-title: Genes Cancer
  doi: 10.1177/1947601911431885
– volume: 7
  year: 2017
  ident: B36
  article-title: The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
  publication-title: Cancer Discovery
  doi: 10.1158/2159-8290.CD-16-0647
– volume: 26
  year: 2014
  ident: B44
  article-title: S100A4 negatively regulates β-catenin by inducing the Egr-1-PTEN-Akt-GSK3β degradation pathway
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2014.06.007
– volume: 272
  year: 1997
  ident: B52
  article-title: Ionizing radiation-inducible apoptosis in the absence of p53 linked to transcription factor EGR-1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.52.33056
– volume: 15
  start-page: 14
  year: 2014
  ident: B70
  article-title: Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter
  publication-title: BMC Mol Biol
  doi: 10.1186/1471-2199-15-14
– volume: 19
  start-page: 791
  year: 2019
  ident: B23
  article-title: Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer
  publication-title: BMC Cancer
  doi: 10.1186/s12885-019-6014-5
– volume: 19
  year: 2017
  ident: B88
  article-title: Correlations of the expressions of c-Jun and Egr-1 proteins with clinicopathological features and prognosis of patients with nasopharyngeal carcinoma
  publication-title: Cancer Biomarkers Section A Dis Markers
  doi: 10.3233/CBM-161710
– volume: 38
  year: 2019
  ident: B12
  article-title: EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0873-8
– volume: 38
  start-page: 61
  year: 2019
  ident: B42
  article-title: Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC
  publication-title: J Exp Clin Cancer Res CR
  doi: 10.1186/s13046-019-1054-x
– volume: 9
  year: 2003
  ident: B48
  article-title: Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
  publication-title: Nat Med
  doi: 10.1038/nm905
– volume: 274
  year: 1999
  ident: B93
  article-title: Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.46.32795
– volume: 11
  year: 2005
  ident: B35
  article-title: Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-04-2071
– volume: 12
  start-page: e0182422
  year: 2017
  ident: B49
  article-title: Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway
  publication-title: PloS One
  doi: 10.1371/journal.pone.0182422
– volume: 323
  year: 2007
  ident: B54
  article-title: Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.107.126193
– volume: 25
  year: 2006
  ident: B37
  article-title: Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601213
– volume: 16
  year: 2015
  ident: B64
  article-title: Early Growth Response Protein-1 Involves in Transforming Growth factor-β1 Induced Epithelial-Mesenchymal Transition and Inhibits Migration of Non-Small-Cell Lung Cancer Cells
  publication-title: Asian Pac J Cancer Prev APJCP
  doi: 10.7314/APJCP.2015.16.9.4137
– volume: 37
  year: 2018
  ident: B72
  article-title: The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation
  publication-title: Oncogene
  doi: 10.1038/onc.2017.359
– volume: 268
  year: 1993
  ident: B5
  article-title: Detection and characterization of cellular EGR-1 binding to its recognition site
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)85286-9
– volume-title: BMB Rep
  year: 2013
  ident: B63
  article-title: Egr-1 regulates the transcription of the BRCA1 gene by etoposide
  doi: 10.5483/BMBRep.2013.46.2.202
– volume: 5
  start-page: 993
  year: 2009
  ident: B33
  article-title: Is EGR1 a potential target for prostate cancer therapy
  publication-title: Future Oncol
  doi: 10.2217/fon.09.67
– volume: 277
  year: 2010
  ident: B57
  article-title: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2’-deoxycytidine-induced PTEN upregulation
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2009.07542.x
– volume: 28
  year: 2017
  ident: B65
  article-title: Oxytocin inhibits head and neck squamous cell carcinoma cell migration by early growth response-1 upregulation
  publication-title: Anti-cancer Drugs
  doi: 10.1097/CAD.0000000000000501
– volume: 10
  start-page: 9285
  year: 2020
  ident: B22
  article-title: Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-66236-x
– volume: 177
  start-page: 70
  year: 2010
  ident: B30
  article-title: Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2010.091164
– volume: 49
  year: 2016
  ident: B11
  article-title: Association and regulation of protein factors of field effect in prostate tissues
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2016.3666
– volume: 270
  year: 2008
  ident: B75
  article-title: Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2008.04.045
– volume: 71
  year: 2007
  ident: B66
  article-title: Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells
  publication-title: Biosci Biotechnol Biochem
  doi: 10.1271/bbb.70103
– volume: 22
  year: 1999
  ident: B95
  article-title: The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience
  publication-title: Trends Neurosci
  doi: 10.1016/S0166-2236(98)01343-5
– volume: 48
  start-page: 38
  year: 2009
  ident: B45
  article-title: The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia
  publication-title: Mol Carcinog
  doi: 10.1002/mc.20454
– volume: 346
  start-page: 6
  year: 2014
  ident: B31
  article-title: Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2013.12.001
SSID ssj0000650103
Score 2.6013992
SecondaryResourceType review_article
Snippet Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis....
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 642547
SubjectTerms angiogenesis
apoptosis
cancer
EGR1
invasion
Oncology
proliferation
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals (ODIN)
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PS8MwFA6yg3gRfzt_EcGLh7olTdPmqGNzCPMwJuwW0jTBwWhlbv-_77Xd6ET04rVN6ev38vK-14TvEXKXeCOkk0kAXDwNhBWwDjoI99gzaxQwep_hf8jRqxy-iZdpNG20-sIzYZU8cAVcRwmfYVaKEmYEN2nqkySSGbAUz01mS51PyHmNYqpagyNsYFDtS0IVpjq-yFGxkLMHYNwRdlNp5KFSrv8njvn9qGQj9wwOyH5NGuljZewh2XH5Edkd1dvixyQEZ9NxMXe08BQYHS0z0Ho9oIOypw7tP48ZneW0h45enJDJoD_pDYO6G0JgI54sAw_FagZfYoViPoVAClMheKoQWslthMrpKnY2NlZC5WmNA7LRtbLLnZfOhaeklRe5OyeUydjI0IsYol34UMHIEHgdNyxlEuK7TTpraLStlcKxYcVcQ8WAYGoEUyOYugKzTe43T3xUKhm_jH1CtDfjUN-6vABe17XX9V9eb5Pbta80xANucpjcFatPXZZMSioGY84q321eBfYAe4xYm8RbXt2yZftOPnsvNbcT4DIwpy7-w_hLsod44Ek2Lq5Ia7lYuWugNsv0ppzFX8Dd8zI
  priority: 102
  providerName: Directory of Open Access Journals
Title The Role of the Transcription Factor EGR1 in Cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/33842351
https://www.proquest.com/docview/2511896913
https://pubmed.ncbi.nlm.nih.gov/PMC8024650
https://doaj.org/article/94fd1512581a42abbf8856d533f2adc3
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8QwEA4-QLyIb9cXEbx4qJpH0-YgouIqwnoQhb2FNE1UWFpdV9B_70zbXV1ZBC-FttM2mczjmySdIWQ_DVYqr9IIsHgWSSfBDnpQ9yQwZzUg-pDjPGTnVl0_yJtu3P3-Pbph4NvE0A7rST30e4cfr5-noPAnGHGCvz0KZYHJCDk7BDAdy2SazIJfSrCeQacB-7VdjrGoAVab40JGWopuvW458SVjfqpK5z8Jg_7eSvnDN7UXyUIDKulZLQVLZMoXy2Su0yybrxABwkDvyp6nZaCA-GjloYb2grarmjv08uqO0eeCXqAg9FfJffvy_uI6aqolRC7m6SAKEMzm0BMnNQsZKJrIpOSZRtYr7mLMrK4T7xLrFESmznoAI8dOHXMflPdijcwUZeE3CGUqsUoEmYA1kEFooBSA-7hlGVOg_y1yNGSNcU0mcSxo0TMQUSAzDTLTIDNNzcwWORg98VJn0fiD9hy5PaLD_NfVhbL_aBp1MlqGHLFKnDIruc2ykKaxygG7Bm5zJ1pkbzhWBvQFF0Fs4cv3N1OFVFppBjTr9diNPgXtAXQZsxZJxkZ1rC3jd4rnpyondwpYB-Rr8x8d3SLzeIYb2rjcJjOD_rvfAYQzyHarmQE4XnXZbiXEX3yO9c0
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+the+Transcription+Factor+EGR1+in+Cancer&rft.jtitle=Frontiers+in+oncology&rft.au=Wang%2C+Bin&rft.au=Guo%2C+Hanfei&rft.au=Yu%2C+Hongquan&rft.au=Chen%2C+Yong&rft.date=2021-03-24&rft.issn=2234-943X&rft.eissn=2234-943X&rft.volume=11&rft_id=info:doi/10.3389%2Ffonc.2021.642547&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fonc_2021_642547
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon