The Role of the Transcription Factor EGR1 in Cancer

Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio...

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Published inFrontiers in oncology Vol. 11; p. 642547
Main Authors Wang, Bin, Guo, Hanfei, Yu, Hongquan, Chen, Yong, Xu, Haiyang, Zhao, Gang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.03.2021
Subjects
angiogenesis
apoptosis
cancer
EGR1
invasion
Oncology
proliferation
EGR1
invasion
proliferation
metastasis
angiogenesis
migration
apoptosis
cancer
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Summary:Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.
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Edited by: Isacco Ferrarini, Brown University, United States
Reviewed by: Yao Tong, The Scripps Research Institute, United States; Xiang Zhao, Huazhong University of Science and Technology, China
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.642547