Bayesian Quantitative Trait Loci Mapping for Multiple Traits

• Published in: Genetics (Austin) Vol. 179; no. 4; pp. 2275 - 2289
• Main Authors: Banerjee, Samprit, Yandell, Brian S, Yi, Nengjun
• Format: Journal Article
• Language: English
• Published: United States Genetics Soc America 01.08.2008; Genetics Society of America
• Subjects: Advantages; Algorithms; Bayes Theorem; Chromosome Mapping - methods; Discriminant analysis; Genetic Linkage; Genetics; Genomics; Investigations; Kidney diseases; Markov Chains; Methods; Monte Carlo Method; Principal components analysis; Quantitative Trait Loci; Studies
• ISSN: 0016-6731; 1943-2631; 1943-2631
• DOI: 10.1534/genetics.108.088427

Most quantitative trait loci (QTL) mapping experiments typically collect phenotypic data on multiple correlated complex traits. However, there is a lack of a comprehensive genomewide mapping strategy for correlated traits in the literature. We develop Bayesian multiple-QTL mapping methods for correlated continuous traits using two multivariate models: one that assumes the same genetic model for all traits, the traditional multivariate model, and the other known as the seemingly unrelated regression (SUR) model that allows different genetic models for different traits. We develop computationally efficient Markov chain Monte Carlo (MCMC) algorithms for performing joint analysis. We conduct extensive simulation studies to assess the performance of the proposed methods and to compare with the conventional single-trait model. Our methods have been implemented in the freely available package R/qtlbim (http://www.qtlbim.org), which greatly facilitates the general usage of the Bayesian methodology for unraveling the genetic architecture of complex traits.