Isobologram Analysis: A Comprehensive Review of Methodology and Current Research

Drug combination is a common method for clinical disease treatment. Whether the combination of drugs is reasonable often affects the result of the disease treatment. Many methods have been used to evaluate interaction between drugs to date. Isobologram analysis has been mathematically proven and wid...

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Published inFrontiers in pharmacology Vol. 10; p. 1222
Main Authors Huang, Ruo-Yue, Pei, Linlin, Liu, QuanJin, Chen, Shiqi, Dou, Haibo, Shu, Gang, Yuan, Zhi-Xiang, Lin, Juchun, Peng, Guangneng, Zhang, Wei, Fu, Hualin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.10.2019
Subjects
application
drug interaction
isobologram analysis
Pharmacology
principle
synergy
principle
synergy
isobologram analysis
application
drug interaction
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Summary:Drug combination is a common method for clinical disease treatment. Whether the combination of drugs is reasonable often affects the result of the disease treatment. Many methods have been used to evaluate interaction between drugs to date. Isobologram analysis has been mathematically proven and widely used to evaluate drug interactions. In this paper, the principle of isobologram analysis and its application in drug interaction evaluation are summarized. The applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are also reviewed. This work is expected to evaluate the effect of formulations scientifically and provide scientific judgment standards for the development of formulations and clinical drug compatibility.
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Edited by: Luc Zimmer, Université Claude Bernard Lyon 1, France
Reviewed by: Ian Edwin Cock, Griffith University, Australia; Hiroaki Goto, Kanagawa Children’s Medical Center, Japan
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2019.01222