Lower cognitive reappraisal capacity is related to impairments in attachment and personality structure in poly-drug use: an fMRI study

• Published in: Brain imaging and behavior Vol. 15; no. 4; pp. 2187 - 2198
• Main Authors: Hiebler-Ragger, M., Perchtold-Stefan, C. M., Unterrainer, H. F., Fuchshuber, J., Koschutnig, K., Nausner, L., Kapfhammer, H. P., Papousek, I., Weiss, E. M., Fink, A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2021; Springer Nature B.V
• Subjects: Adult; Attachment; Biomedical and Life Sciences; Biomedicine; Brain mapping; Cognition; Cognitive ability; Drug use; Emotions; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Personality; Pharmaceutical Preparations; Psychiatry; Questionnaires; Substance-Related Disorders - diagnostic imaging; fMRI; Attachment; Polydrug use; Emotion regulation; Cognitive reappraisal
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-020-00414-3

Insecure attachment, impaired personality structure and impaired emotion regulation figure prominently in substance use disorders. While negative emotions can trigger drug-use and relapse, cognitive reappraisal may reduce emotional strain by promoting changes in perspective. In the present study, we explored behavioral and neural correlates of cognitive reappraisal in poly-drug use disorder by testing individuals’ capability to generate cognitive reappraisals for aversive events (Reappraisal Inventiveness Test). 18 inpatients with poly-drug use disorder and 16 controls completed the Adult Attachment Scale, the Emotion Regulation Questionnaire, the Brief Symptom Inventory, the Wonderlic Personnel Test, and the Operationalized Psychodynamic Diagnosis Structure Questionnaire, as well as two versions of the Reappraisal Inventiveness Test (during fMRI and outside the lab). Compared to controls, polydrug inpatients reported impaired personality structure, attachment and emotion regulation abilities. In the Reappraisal Inventiveness Test, poly-drug inpatients were less flexible and fluent in generating reappraisals for anger-eliciting situations. Corresponding to previous brain imaging evidence, cognitive reappraisal efforts of both groups were reflected in activation of left frontal regions, particularly left superior and middle frontal gyri and left supplemental motor areas. However, no group differences in neural activation patterns emerged. This suggests that despite cognitive reappraisal impairments on a behavioral level, neural reflections of these deficits in poly-drug use disorder might be more complex.