The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and...

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Published inFrontiers in endocrinology (Lausanne) Vol. 11; p. 365
Main Authors Ge, Tongxin, Yang, Jiawen, Zhou, Shihui, Wang, Yuchen, Li, Yakui, Tong, Xuemei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.06.2020
Subjects
Animals
cancer
diabetes
Diabetes Mellitus, Type 2 - metabolism
Endocrinology
Humans
Insulin - metabolism
Insulin Resistance
metabolism
Neoplasms - metabolism
obesity
Oxidation-Reduction
Oxidative Stress
Pentose Phosphate Pathway
the pentose phosphate pathway
cancer
metabolism
the pentose phosphate pathway
diabetes
obesity
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Summary:The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Reviewed by: Lei Jiang, City of Hope National Medical Center, United States; Matthew J. Brady, University of Chicago, United States
These authors have contributed equally to this work
Edited by: Debbie C. Thurmond, Beckman Research Institute, City of Hope, United States
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.00365