Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV

• Published in: Vaccine Vol. 34; no. 48; pp. 5886 - 5894
• Main Authors: Poteet, Ethan, Lewis, Phoebe, Chen, Changyi, Ho, Sam On, Do, Thai, Chiang, SuMing, Labranche, Celia, Montefiori, David, Fujii, Gary, Yao, Qizhi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 21.11.2016; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; Adjuvants, Immunologic - chemistry; AIDS; AIDS Vaccines - immunology; Allergy and Immunology; Animals; Antibodies, Neutralizing - blood; Antigens; Colleges & universities; Conflicts of interest; Drug dosages; Gene Products, gag - immunology; Germinal center; Germinal Center - immunology; HIV; HIV Antibodies - blood; HIV Infections - immunology; HIV Infections - prevention & control; HIV-1 - immunology; Human immunodeficiency virus; Immunity, Humoral; Lentivirus; Ligands; Lipids; Mice; Mice, Inbred C57BL; Neutralizing antibody; Retroviridae; T-Lymphocytes, Cytotoxic - immunology; TLR3; Toll-Like Receptor 3 - chemistry; Toll-Like Receptor 3 - immunology; Vaccine; Vaccines, Synthetic - immunology; Vaccines, Virus-Like Particle - administration & dosage; Vaccines, Virus-Like Particle - chemistry; Vaccines, Virus-Like Particle - immunology; Virus Like Particle (VLP); Virus Like Particle (VLP); Vaccine; HIV; Germinal center; TLR3; Neutralizing antibody
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.10.036

Highlights • VLPs in combination with TLR3 adjuvant induce a strong humoral response. • VLPs in combination with TLR3 adjuvant induced most potent neutralizing antibodies. • Correlation between germinal centers and potency of neutralizing antibodies.