Plasma Heat Shock Proteins (HSPs) 70 and 47 levels in diabetic foot and its possible correlation with clinical variables in a North Indian Tertiary care hospital

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 9; no. 4; pp. 237 - 243
• Main Authors: Zubair, Mohammad, Ahmad, Jamal
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2015
• Subjects: Biomarkers - blood; Blood Glucose - metabolism; Case-Control Studies; Correlation; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - complications; Diabetic Foot - blood; Diabetic Foot - etiology; Diabetic Foot - physiopathology; Diabetic foot ulcer; Endocrinology & Metabolism; Female; Follow-Up Studies; HSP47 Heat-Shock Proteins - blood; HSP70 Heat-Shock Proteins - blood; Humans; India; Male; Middle Aged; Outcome; Plasma HSPs (70 and 47); Prognosis; Prospective Studies; Risk Factors; Tertiary Healthcare; India; Plasma HSPs (70 and 47); Correlation; Diabetic foot ulcer; Outcome
• ISSN: 1871-4021; 1878-0334; 1878-0334
• DOI: 10.1016/j.dsx.2015.02.015

HSPs have been proposed to have a role in the wound healing process, supported by finding that its expression is rapidly induced after skin is wounded in animal models. Because of this phenomenon, we have made a hypothesis that circulating HSPs will have any relationship with DFU. The circulating levels of HSP 70 and HSP 47 were measured in diabetic patients with an ulcer (Group A: n=30), without ulcer (Group B: n=30) and healthy subjects (Group C: n=30). Diabetic foot ulcer showed higher median plasma level of HSP 70 [3229.01 (1984.5–4137.1) vs 1625.7 (1435.1–2253.5) vs 1025.7 (835.1–1653.5)] ng/ml and HSP 47 [2.33 (2.118–2.58) vs 0.98 (0.83–1.07) vs 0.58 (0.42–0.68) pg/ml] of the diabetic foot, diabetic control and healthy subjects. Odds ratio and risk ratio for DFU after age adjusted were BMI (>25kg/m2) [OR 1.78, RR 1.35], HbA1c>7% [OR 3.37), RR 1.76], neuropathy [OR 5.79, RR 3.13], retinopathy [OR 3.44, RR 1.82], hypertension [OR 1.54, RR 1.18], and smoking cessation [OR 4.53, RR 2.09]. In the near future, it would be interesting to find out whether this high plasma HSPs precedes in early would healing mechanism and will have a relationship with type of infections and/or nature of therapy for infection in such patients.