An Update on Candida tropicalis Based on Basic and Clinical Approaches

• Published in: Frontiers in microbiology Vol. 8; p. 1927
• Main Authors: Zuza-Alves, Diana L., Silva-Rocha, Walicyranison P., Chaves, Guilherme M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.10.2017
• Subjects: antifungal resistance; Candida tropicalis; Microbiology; phenotypic and molecular identification; update; virulence factors; Candida tropicalis; update; antifungal resistance; virulence factors; phenotypic and molecular identification
• ISSN: 1664-302X; 1664-302X
• DOI: 10.3389/fmicb.2017.01927

has emerged as one of the most important species. It has been widely considered the second most virulent species, only preceded by . Besides, this species has been recognized as a very strong biofilm producer, surpassing in most of the studies. In addition, it produces a wide range of other virulence factors, including: adhesion to buccal epithelial and endothelial cells; the secretion of lytic enzymes, such as proteinases, phospholipases, and hemolysins, bud-to-hyphae transition (also called morphogenesis) and the phenomenon called phenotypic switching. This is a species very closely related to and has been easily identified with both phenotypic and molecular methods. In addition, no cryptic sibling species were yet described in the literature, what is contradictory to some other medically important species. is a clinically relevant species and may be the second or third etiological agent of candidemia, specifically in Latin American countries and Asia. Antifungal resistance to the azoles, polyenes, and echinocandins has already been described. Apart from all these characteristics, has been considered an osmotolerant microorganism and this ability to survive to high salt concentration may be important for fungal persistence in saline environments. This physiological characteristic makes this species suitable for use in biotechnology processes. Here we describe an update of , focusing on all these previously mentioned subjects.