The Many and Varied Roles of Tetraspanins in Immune Cell Recruitment and Migration

Immune cell recruitment and migration is central to the normal functioning of the immune system in health and disease. Numerous adhesion molecules on immune cells and the parenchymal cells they interact with are well recognized for their roles in facilitating the movements of immune cells throughout...

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Published inFrontiers in immunology Vol. 9; p. 1644
Main Authors Yeung, Louisa, Hickey, Michael J, Wright, Mark D
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.07.2018
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Summary:Immune cell recruitment and migration is central to the normal functioning of the immune system in health and disease. Numerous adhesion molecules on immune cells and the parenchymal cells they interact with are well recognized for their roles in facilitating the movements of immune cells throughout the body. A growing body of evidence now indicates that tetraspanins, proteins known for their capacity to organize partner molecules within the cell membrane, also have significant impacts on the ability of immune cells to migrate around the body. In this review, we examine the tetraspanins expressed by immune cells and endothelial cells that influence leukocyte recruitment and motility and describe their impacts on the function of adhesion molecules and other partner molecules that modulate the movements of leukocytes. In particular, we examine the functional roles of CD9, CD37, CD63, CD81, CD82, and CD151. This reveals the diversity of the functions of the tetraspanin family in this setting, both in the nature of adhesive and migratory interactions that they regulate, and the positive or inhibitory effects mediated by the individual tetraspanin proteins.
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Edited by: Carlos Cabañas, Consejo Superior de Investigaciones Científicas (CSIC), Spain
Reviewed by: Francisco Sanchez-Madrid, Universidad Autonoma de Madrid, Spain; Martin Johannes Hoogduijn, Erasmus University Rotterdam, Netherlands; Eric Rubinstein, INSERM U935 Modèles de Cellules Souches Malignes et Thérapeutiques, France
Specialty section: This article was submitted to Antigen Presenting Cell Biology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.01644