Coronary microvascular disease in hypertrophic and infiltrative cardiomyopathies

• Published in: Journal of nuclear cardiology Vol. 30; no. 2; pp. 800 - 810
• Main Authors: Giannopoulos, Andreas A., Buechel, Ronny R., Kaufmann, Philipp A.
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.04.2023; Springer International Publishing; Springer Nature B.V
• Subjects: cardiac PET; Cardiology; Cardiomyopathies - pathology; CMD; CMR; Coronary Artery Disease - pathology; Coronary Circulation - physiology; coronary flow reserve; Coronary microvascular disease; Humans; Hypertrophy - pathology; Imaging; left ventricular hypertrophy; Medicine; Medicine & Public Health; Microcirculation; Myocardium - pathology; Nuclear Medicine; Radiology; Theme; Theme Articles; Tomography, X-Ray Computed; CMR; Coronary microvascular disease; CS; MBF; cardiac PET; coronary flow reserve; HCM; left ventricular hypertrophy; MFR; CMD; CA; PET; AFD; LVH
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1007/s12350-022-03040-2

Pathologic hypertrophy of the cardiac muscle is a commonly encountered phenotype in clinical practice, associated with a variety of structural and non-structural diseases. Coronary microvascular disease is considered to play an important role in the natural history of this pathological phenotype. Non-invasive imaging modalities, most prominently positron emission tomography and cardiac magnetic resonance, have provided insights into the pathophysiological mechanisms of the interplay between hypertrophy and the coronary microvasculature. This article summarizes the current knowledge on coronary microvascular dysfunction in the most frequently encountered forms of pathologic hypertrophy.